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Selective Macrocyclic Inhibitors of DYRK1A/B.
Powell CE, Hatcher JM, Jiang J, Vatsan PS, Che J, Gray NS. Powell CE, et al. ACS Med Chem Lett. 2022 Mar 8;13(4):577-585. doi: 10.1021/acsmedchemlett.1c00630. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450378 Free PMC article.
Benzopyrimidodiazepinone inhibitors of TNK2.
Groendyke BJ, Powell CE, Feru F, Gero TW, Li Z, Szabo H, Pang K, Feutrill J, Chen B, Li B, Gray NS, Scott DA. Groendyke BJ, et al. Among authors: powell ce. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126948. doi: 10.1016/j.bmcl.2020.126948. Epub 2020 Jan 7. Bioorg Med Chem Lett. 2020. PMID: 31928839
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS. Powell CE, et al. J Med Chem. 2018 May 10;61(9):4249-4255. doi: 10.1021/acs.jmedchem.7b01655. Epub 2018 Apr 24. J Med Chem. 2018. PMID: 29660984 Free PMC article.
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform.
Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. Hatcher JM, et al. Among authors: powell ce. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. doi: 10.1016/j.chembiol.2018.01.013. Epub 2018 Feb 22. Cell Chem Biol. 2018. PMID: 29478907 Free PMC article.
45 results