Savva CG - Search Results

1

Cryo-electron microscopy structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis.

Johnston HE, Batt SM, Brown AK, Savva CG, Besra GS, Fütterer K. Johnston HE, et al. Among authors: savva cg. Microbiology (Reading). 2024 Oct;170(10). doi: 10.1099/mic.0.001505. Microbiology (Reading). 2024. PMID: 39412527 Free article.

2

Structure of Aquifex aeolicus lumazine synthase by cryo-electron microscopy to 1.42 Å resolution.

Savva CG, Sobhy MA, De Biasio A, Hamdan SM. Savva CG, et al. IUCrJ. 2024 Sep 1;11(Pt 5):723-729. doi: 10.1107/S2052252524005530. IUCrJ. 2024. PMID: 38965901 Free PMC article.

3

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO₂.

Brotherton DH, Nijjar S, Savva CG, Dale N, Cameron AD. Brotherton DH, et al. Among authors: savva cg. Elife. 2024 Jun 3;13:RP93686. doi: 10.7554/eLife.93686. Elife. 2024. PMID: 38829031 Free PMC article.

4

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.

Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W. Gruszczyk J, et al. Among authors: savva cg. Nat Commun. 2022 Nov 16;13(1):7010. doi: 10.1038/s41467-022-34773-w. Nat Commun. 2022. PMID: 36385050 Free PMC article.

5

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding.

Bate N, Savva CG, Moody PCE, Brown EA, Evans SE, Ball JK, Schwabe JWR, Sale JE, Brindle NPJ. Bate N, et al. Among authors: savva cg. PLoS Pathog. 2022 Jul 18;18(7):e1010733. doi: 10.1371/journal.ppat.1010733. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35849637 Free PMC article.

6

Conformational changes and CO₂-induced channel gating in connexin26.

Brotherton DH, Savva CG, Ragan TJ, Dale N, Cameron AD. Brotherton DH, et al. Among authors: savva cg. Structure. 2022 May 5;30(5):697-706.e4. doi: 10.1016/j.str.2022.02.010. Epub 2022 Mar 10. Structure. 2022. PMID: 35276081 Free PMC article.

7

The topology of chromatin-binding domains in the NuRD deacetylase complex.

Millard CJ, Fairall L, Ragan TJ, Savva CG, Schwabe JWR. Millard CJ, et al. Among authors: savva cg. Nucleic Acids Res. 2020 Dec 16;48(22):12972-12982. doi: 10.1093/nar/gkaa1121. Nucleic Acids Res. 2020. PMID: 33264408 Free PMC article.

8

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.

Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR. Turnbull RE, et al. Among authors: savva cg. Nat Commun. 2020 Jun 26;11(1):3252. doi: 10.1038/s41467-020-17078-8. Nat Commun. 2020. PMID: 32591534 Free PMC article.

9

Structure of the processive human Pol δ holoenzyme.

Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A. Lancey C, et al. Among authors: savva cg. Nat Commun. 2020 Feb 28;11(1):1109. doi: 10.1038/s41467-020-14898-6. Nat Commun. 2020. PMID: 32111820 Free PMC article.

10

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.

Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR. Song Y, et al. Among authors: savva cg. Cell Rep. 2020 Feb 25;30(8):2699-2711.e8. doi: 10.1016/j.celrep.2020.01.091. Cell Rep. 2020. PMID: 32101746 Free PMC article.

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