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Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.
Ross JL, Puigdelloses-Vallcorba M, Piñero G, Soni N, Thomason W, DeSisto J, Angione A, Tsankova NM, Castro MG, Schniederjan M, Wadhwani NR, Raju GP, Morgenstern P, Becher OJ, Green AL, Tsankov AM, Hambardzumyan D. Ross JL, et al. Among authors: castro mg. Immunity. 2024 Nov 12;57(11):2669-2687.e6. doi: 10.1016/j.immuni.2024.09.007. Epub 2024 Oct 11. Immunity. 2024. PMID: 39395421
Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.
Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley L, Chandler JP, Stupp R, Sonabend AM, Horbinski CM, Lukas RV, Xiu J, Lopez G, Nicolaides TP, Brown V, Wadhwani NR, Lam SK, James CD, Rao G, Castro MG, Heimberger AB, DeCuypere M. Tripathi S, et al. Among authors: castro mg. J Clin Invest. 2024 Aug 13;134(19):e177413. doi: 10.1172/JCI177413. J Clin Invest. 2024. PMID: 39137048 Free PMC article.
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma.
Peterson ER, Sajjakulnukit P, Scott AJ, Heaslip C, Andren A, Wilder-Romans K, Zhou W, Palavalasa S, Korimerla N, Lin A, O'Brien A, Kothari A, Zhao Z, Zhang L, Morgan MA, Venneti S, Koschmann C, Jabado N, Lyssiotis CA, Castro MG, Wahl DR. Peterson ER, et al. Among authors: castro mg. Cancer Metab. 2024 Apr 9;12(1):11. doi: 10.1186/s40170-024-00341-7. Cancer Metab. 2024. PMID: 38594734 Free PMC article.
Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma.
Peterson ER, Sajjakulnukit P, Scott AJ, Heaslip C, Andren A, Wilder-Romans K, Zhou W, Palavalasa S, Korimerla N, Lin A, Obrien A, Kothari A, Zhao Z, Zhang L, Morgan MA, Venneti S, Koschmann C, Jabado N, Lyssiotis CA, Castro MG, Wahl DR. Peterson ER, et al. Among authors: castro mg. Res Sq [Preprint]. 2023 Sep 11:rs.3.rs-3317816. doi: 10.21203/rs.3.rs-3317816/v1. Res Sq. 2023. Update in: Cancer Metab. 2024 Apr 9;12(1):11. doi: 10.1186/s40170-024-00341-7 PMID: 37790517 Free PMC article. Updated. Preprint.
Blood-brain barrier remodeling in an organ-on-a-chip device shows Dkk1 to be a regulator of early metastasis.
Westerhof TM, Yang BA, Merill NM, Yates JA, Altemus M, Russell L, Miller AJ, Bao L, Wu Z, Ulintz PJ, Aguilar CA, Morikawa A, Castro MG, Merajver SD, Oliver CR. Westerhof TM, et al. Among authors: castro mg. Adv Nanobiomed Res. 2023 Apr;3(4):2200036. doi: 10.1002/anbr.202200036. Epub 2023 Feb 5. Adv Nanobiomed Res. 2023. PMID: 37234365 Free PMC article.
Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles.
Mauser A, Waibel I, Banerjee K, Mujeeb AA, Gan J, Lee S, Brown W, Lang N, Gregory J, Raymond J, Franzeb M, Schwendeman A, Castro MG, Lahann J. Mauser A, et al. Among authors: castro mg. Adv Ther (Weinh). 2024 Nov;7(11):2400208. doi: 10.1002/adtp.202400208. Epub 2024 Jun 27. Adv Ther (Weinh). 2024. PMID: 39575154 Free PMC article.
Foundation models for fast, label-free detection of glioma infiltration.
Kondepudi A, Pekmezci M, Hou X, Scotford K, Jiang C, Rao A, Harake ES, Chowdury A, Al-Holou W, Wang L, Pandey A, Lowenstein PR, Castro MG, Koerner LI, Roetzer-Pejrimovsky T, Widhalm G, Camelo-Piragua S, Movahed-Ezazi M, Orringer DA, Lee H, Freudiger C, Berger M, Hervey-Jumper S, Hollon T. Kondepudi A, et al. Among authors: castro mg. Nature. 2024 Nov 13. doi: 10.1038/s41586-024-08169-3. Online ahead of print. Nature. 2024. PMID: 39537921
457 results