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Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.
Phillips E, van Enk S, Kildgaard S, Schlue S, Göttmann M, Jennings V, Bethke F, Müller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V. Phillips E, et al. Among authors: schlue s. Mol Oncol. 2024 Oct 27. doi: 10.1002/1878-0261.13756. Online ahead of print. Mol Oncol. 2024. PMID: 39462997 Free article.
Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma.
Alhalabi OT, Göttmann M, Gold MP, Schlue S, Hielscher T, Iskar M, Kessler T, Hai L, Lokumcu T, Cousins CC, Herold-Mende C, Heßling B, Horschitz S, Jabali A, Koch P, Baumgartner U, Day BW, Wick W, Sahm F, Krieg SM, Fraenkel E, Phillips E, Goidts V. Alhalabi OT, et al. Among authors: schlue s. Cancer Lett. 2024 Nov 28;605:217265. doi: 10.1016/j.canlet.2024.217265. Epub 2024 Sep 25. Cancer Lett. 2024. PMID: 39332586 Free article.
A novel patient stratification strategy to enhance the therapeutic efficacy of dasatinib in glioblastoma.
Alhalabi OT, Fletcher MNC, Hielscher T, Kessler T, Lokumcu T, Baumgartner U, Wittmann E, Schlue S, Göttmann M, Rahman S, Hai L, Hansen-Palmus L, Puccio L, Nakano I, Herold-Mende C, Day BW, Wick W, Sahm F, Phillips E, Goidts V. Alhalabi OT, et al. Among authors: schlue s. Neuro Oncol. 2022 Jan 5;24(1):39-51. doi: 10.1093/neuonc/noab158. Neuro Oncol. 2022. PMID: 34232320 Free PMC article.