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DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming.
Gritti I, Wan J, Weeresekara V, Vaz JM, Tarantino G, Bryde TH, Vijay V, Kammula AV, Kattel P, Zhu S, Vu P, Chan M, Wu MJ, Gordan JD, Patra KC, Silveira VS, Manguso RT, Wein MN, Ott CJ, Qi J, Liu D, Sakamoto K, Gujral TS, Bardeesy N. Gritti I, et al. Among authors: sakamoto k. Cancer Discov. 2024 Sep 27. doi: 10.1158/2159-8290.CD-24-0634. Online ahead of print. Cancer Discov. 2024. PMID: 39326063
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N. Patra KC, et al. Among authors: sakamoto k. Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941929 Free PMC article.
SIKs control osteocyte responses to parathyroid hormone.
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Wein MN, et al. Among authors: sakamoto k. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. Nat Commun. 2016. PMID: 27759007 Free PMC article.
Corrigendum: SIKs control osteocyte responses to parathyroid hormone.
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Wein MN, et al. Among authors: sakamoto k. Nat Commun. 2017 Feb 22;8:14745. doi: 10.1038/ncomms14745. Nat Commun. 2017. PMID: 28224982 Free PMC article. No abstract available.
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K. Patel K, et al. Among authors: sakamoto k. Nat Commun. 2014 Aug 4;5:4535. doi: 10.1038/ncomms5535. Nat Commun. 2014. PMID: 25088745 Free PMC article.
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.
Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. Fujii N, et al. Among authors: sakamoto k. Am J Physiol Cell Physiol. 2004 Jul;287(1):C200-8. doi: 10.1152/ajpcell.00415.2003. Epub 2004 Mar 10. Am J Physiol Cell Physiol. 2004. PMID: 15013949 Free article.
4,884 results