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DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming.
Gritti I, Wan J, Weeresekara V, Vaz JM, Tarantino G, Bryde TH, Vijay V, Kammula AV, Kattel P, Zhu S, Vu P, Chan M, Wu MJ, Gordan JD, Patra KC, Silveira VS, Manguso RT, Wein MN, Ott CJ, Qi J, Liu D, Sakamoto K, Gujral TS, Bardeesy N. Gritti I, et al. Among authors: patra kc. Cancer Discov. 2024 Sep 27. doi: 10.1158/2159-8290.CD-24-0634. Online ahead of print. Cancer Discov. 2024. PMID: 39326063
A Cell Size Theory of Aging.
Patra KC, Bardeesy N. Patra KC, et al. Dev Cell. 2018 Jun 18;45(6):665-666. doi: 10.1016/j.devcel.2018.06.001. Dev Cell. 2018. PMID: 29920272 Free article.
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N. Patra KC, et al. Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941929 Free PMC article.
AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth.
Patra KC, Weerasekara VK, Bardeesy N. Patra KC, et al. Cell Metab. 2019 Feb 5;29(2):238-240. doi: 10.1016/j.cmet.2018.12.011. Epub 2019 Jan 3. Cell Metab. 2019. PMID: 30612899 Free article.
TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.
Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leschiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, Reyes S, Sagara T, Otsuki S, Nadres B, Shahzade HA, Dey-Guha I, Fetter IJ, Baiev I, Van Seventer EE, Murphy JE, Ferrone CR, Tanabe KK, Deshpande V, Harding JJ, Yaeger R, Kelley RK, Bardelli A, Iafrate AJ, Hahn WC, Benes CH, Ting DT, Hirai H, Getz G, Juric D, Zhu AX, Corcoran RB, Bardeesy N. Goyal L, et al. Among authors: patra kc. Cancer Discov. 2019 Aug;9(8):1064-1079. doi: 10.1158/2159-8290.CD-19-0182. Epub 2019 May 20. Cancer Discov. 2019. PMID: 31109923 Free PMC article.
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.
Chan GKL, Maisel S, Hwang YC, Pascual BC, Wolber RRB, Vu P, Patra KC, Bouhaddou M, Kenerson HL, Lim HC, Long D, Yeung RS, Sethupathy P, Swaney DL, Krogan NJ, Turnham RE, Riehle KJ, Scott JD, Bardeesy N, Gordan JD. Chan GKL, et al. Among authors: patra kc. Elife. 2023 Jan 24;12:e69521. doi: 10.7554/eLife.69521. Elife. 2023. PMID: 36692000 Free PMC article.
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LW. Qiao S, et al. Among authors: patra kc. Genes Dev. 2020 Jun 1;34(11-12):751-766. doi: 10.1101/gad.335166.119. Epub 2020 Apr 9. Genes Dev. 2020. PMID: 32273287 Free PMC article.
39 results