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Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery.
Qian C, Zhou Y, Zhang T, Dong G, Song M, Tang Y, Wei Z, Yu S, Shen Q, Chen W, Choi JP, Yan J, Zhong C, Wan L, Li J, Wang A, Lu Y, Zhao Y. Qian C, et al. Among authors: tang y. Acta Pharm Sin B. 2024 May;14(5):2077-2096. doi: 10.1016/j.apsb.2024.02.003. Epub 2024 Feb 23. Acta Pharm Sin B. 2024. PMID: 38799619 Free PMC article.
Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier.
Zheng W, Shen P, Yu C, Tang Y, Qian C, Yang C, Gao M, Wu Y, Yu S, Tang W, Wan G, Wang A, Lu Y, Zhao Y. Zheng W, et al. Among authors: tang w, tang y. Pharmacol Res. 2023 Dec;198:106986. doi: 10.1016/j.phrs.2023.106986. Epub 2023 Nov 7. Pharmacol Res. 2023. PMID: 37944834 Free article.
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers.
Xia RX, Zou PC, Xie JT, Tang YB, Gong MM, Fan F, Aihemaiti A, Liu YQ, Shen Y, Zhou BS, Zhu L, Lei HM. Xia RX, et al. Among authors: tang yb. Acta Pharmacol Sin. 2024 Nov 6. doi: 10.1038/s41401-024-01409-2. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 39506063
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