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Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation.
Heintzman DR, Sinard RC, Fisher EL, Ye X, Patterson AR, Elasy JH, Voss K, Chi C, Sugiura A, Rodriguez-Garcia GJ, Chowdhury NU, Arner EN, Krystoviak ES, Mason FM, Toudji YT, Steiner KK, Khan W, Olson LM, Jones AL, Hong HS, Bass L, Beier KL, Deng W, Lyssiotis CA, Newcomb DC, Bick AG, Rathmell WK, Wilson JT, Rathmell JC. Heintzman DR, et al. Among authors: rathmell jc. Sci Immunol. 2024 Sep 20;9(99):eadp3475. doi: 10.1126/sciimmunol.adp3475. Epub 2024 Sep 20. Sci Immunol. 2024. PMID: 39303018
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. Arreola A, et al. Among authors: rathmell jc, rathmell wk. PLoS One. 2014 May 30;9(5):e98705. doi: 10.1371/journal.pone.0098705. eCollection 2014. PLoS One. 2014. PMID: 24879016 Free PMC article.
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. Kishton RJ, et al. Among authors: rathmell jc, rathmell wk. Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008. Cell Metab. 2016. PMID: 27076078 Free PMC article.
Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling.
Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB. Siska PJ, et al. Among authors: rathmell jc, rathmell wk. Oncoimmunology. 2017 Mar 20;6(4):e1305535. doi: 10.1080/2162402X.2017.1305535. eCollection 2017. Oncoimmunology. 2017. PMID: 28507813 Free PMC article.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Siska PJ, et al. Among authors: rathmell jc, rathmell wk. JCI Insight. 2017 Jun 15;2(12):e93411. doi: 10.1172/jci.insight.93411. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614802 Free PMC article.
Metabolic Barriers to T Cell Function in Tumors.
Sugiura A, Rathmell JC. Sugiura A, et al. Among authors: rathmell jc. J Immunol. 2018 Jan 15;200(2):400-407. doi: 10.4049/jimmunol.1701041. J Immunol. 2018. PMID: 29311381 Free PMC article. Review.
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.
Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC. Johnson MO, et al. Among authors: rathmell jc, rathmell wk. Cell. 2018 Dec 13;175(7):1780-1795.e19. doi: 10.1016/j.cell.2018.10.001. Epub 2018 Nov 1. Cell. 2018. PMID: 30392958 Free PMC article.
Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing.
Raddatz MA, Huffstater T, Bersi MR, Reinfeld BI, Madden MZ, Booton SE, Rathmell WK, Rathmell JC, Lindman BR, Madhur MS, Merryman WD. Raddatz MA, et al. Among authors: rathmell jc, rathmell wk. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):e153-e165. doi: 10.1161/ATVBAHA.120.314360. Epub 2020 Apr 16. Arterioscler Thromb Vasc Biol. 2020. PMID: 32295422 Free PMC article.
229 results