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Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
Tellis JC, Wei B, Siu M, An L, Chan GK, Chen Y, Du X, Gazzard L, Hu B, Kiefer J, Kakiuchi-Kiyota S, Lainchbury M, Linehan JL, Luo X, Malhotra S, Mendonca R, Pang J, Ran Y, Sethuraman V, Seward E, Sneeringer C, Su D, Wang W, Wu P, Moffat JG, Heffron TP, Choo EF, Chan BK. Tellis JC, et al. Among authors: ran y. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614. doi: 10.1021/acsmedchemlett.4c00319. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291002
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Yulyaningsih E, Suh JH, Fanok M, Chau R, Solanoy H, Takahashi R, Bakardjiev AI, Becerra I, Benitez NB, Chiu CL, Davis SS, Dowdle WE, Earr T, Estrada AA, Gill A, Ha C, Haddick PCG, Henne KR, Larhammar M, Leung AW, Maciuca R, Memarzadeh B, Nguyen HN, Nugent AA, Osipov M, Ran Y, Rebadulla K, Roche E, Sandman T, Wang J, Lewcock JW, Scearce-Levie K, Kane LA, Sanchez PE. Yulyaningsih E, et al. Among authors: ran y. Elife. 2024 Sep 17;12:RP92173. doi: 10.7554/eLife.92173. Elife. 2024. PMID: 39287504 Free PMC article.
1,164 results