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Hyperactive Nickase Activity Improves Adenine Base Editing.
Gandadireja AP, Vos PD, Siira SJ, Filipovska A, Rackham O. Gandadireja AP, et al. ACS Synth Biol. 2024 Oct 18;13(10):3128-3136. doi: 10.1021/acssynbio.4c00407. Epub 2024 Sep 19. ACS Synth Biol. 2024. PMID: 39298405
Mutational rescue of the activity of high-fidelity Cas9 enzymes.
Vos PD, Gandadireja AP, Rossetti G, Siira SJ, Mantegna JL, Filipovska A, Rackham O. Vos PD, et al. Among authors: gandadireja ap. Cell Rep Methods. 2024 Apr 22;4(4):100756. doi: 10.1016/j.crmeth.2024.100756. Epub 2024 Apr 11. Cell Rep Methods. 2024. PMID: 38608689 Free PMC article.
Computationally designed hyperactive Cas9 enzymes.
Vos PD, Rossetti G, Mantegna JL, Siira SJ, Gandadireja AP, Bruce M, Raven SA, Khersonsky O, Fleishman SJ, Filipovska A, Rackham O. Vos PD, et al. Among authors: gandadireja ap. Nat Commun. 2022 May 31;13(1):3023. doi: 10.1038/s41467-022-30598-9. Nat Commun. 2022. PMID: 35641498 Free PMC article.