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Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
Nishimori S, O'Meara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Jüppner H, Kronenberg HM, Wein MN. Nishimori S, et al. Among authors: wein mn. J Clin Invest. 2019 Dec 2;129(12):5187-5203. doi: 10.1172/JCI130126. J Clin Invest. 2019. PMID: 31430259 Free PMC article.
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Tang CC, Castro Andrade CD, O'Meara MJ, Yoon SH, Sato T, Brooks DJ, Bouxsein ML, Martins JDS, Wang J, Gray NS, Misof B, Roschger P, Blouin S, Klaushofer K, Velduis-Vlug A, Vegting Y, Rosen CJ, O'Connell D, Sundberg TB, Xavier RJ, Ung P, Schlessinger A, Kronenberg HM, Berdeaux R, Foretz M, Wein MN. Tang CC, et al. Among authors: wein mn. Elife. 2021 Jun 23;10:e67772. doi: 10.7554/eLife.67772. Elife. 2021. PMID: 34160349 Free PMC article.
A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.
Yoon SH, Meyer MB, Arevalo C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss K, Sato T, Benkusky NA, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN. Yoon SH, et al. Among authors: wein mn. J Clin Invest. 2023 May 1;133(9):e163627. doi: 10.1172/JCI163627. J Clin Invest. 2023. PMID: 36862513 Free PMC article.
The Role of Wnt Signaling in Postnatal Tooth Root Development.
Tokavanich N, Wein MN, English JD, Ono N, Ono W. Tokavanich N, et al. Among authors: wein mn. Front Dent Med. 2021;2:769134. doi: 10.3389/fdmed.2021.769134. Epub 2021 Nov 12. Front Dent Med. 2021. PMID: 35782525 Free PMC article.
SP7: from Bone Development to Skeletal Disease.
Wang JS, Tokavanich N, Wein MN. Wang JS, et al. Among authors: wein mn. Curr Osteoporos Rep. 2023 Apr;21(2):241-252. doi: 10.1007/s11914-023-00778-7. Epub 2023 Mar 7. Curr Osteoporos Rep. 2023. PMID: 36881265 Free PMC article. Review.
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice.
Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U, Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN. Sato T, et al. Among authors: wein mn. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2214396119. doi: 10.1073/pnas.2214396119. Epub 2022 Dec 6. Proc Natl Acad Sci U S A. 2022. PMID: 36472957 Free PMC article.
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