Zhang Y - Search Results

1

Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant.

Heaton GR, Li X, Zhou X, Zhang Y, Vu DT, Oeller M, Karayel O, Hoang QQ, Kars ME, Wang M, Tarassishin L, Mann M, Peter I, Yue Z. Heaton GR, et al. Among authors: zhang y. bioRxiv [Preprint]. 2024 Sep 5:2024.09.05.611530. doi: 10.1101/2024.09.05.611530. bioRxiv. 2024. PMID: 39282291 Free PMC article. Preprint.

2

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.

Pan PY, Li X, Wang J, Powell J, Wang Q, Zhang Y, Chen Z, Wicinski B, Hof P, Ryan TA, Yue Z. Pan PY, et al. Among authors: zhang y. J Neurosci. 2017 Nov 22;37(47):11366-11376. doi: 10.1523/JNEUROSCI.0964-17.2017. Epub 2017 Oct 20. J Neurosci. 2017. PMID: 29054882 Free PMC article.

3

The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.

Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z, Zhang B. Wang Q, et al. Among authors: zhang b, zhang y. Nat Commun. 2019 Nov 20;10(1):5234. doi: 10.1038/s41467-019-13144-y. Nat Commun. 2019. PMID: 31748532 Free PMC article.

4

Rit2 silencing in dopamine neurons drives a Parkinsonian phenotype.

Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE. Kearney PJ, et al. Among authors: zhang y. bioRxiv [Preprint]. 2023 Nov 13:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. bioRxiv. 2023. PMID: 37162843 Free PMC article. Preprint.

5

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes.

Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z. Li X, et al. Among authors: zhang y. bioRxiv [Preprint]. 2024 Jul 19:2024.07.17.603999. doi: 10.1101/2024.07.17.603999. bioRxiv. 2024. Update in: Nat Commun. 2024 Sep 29;15(1):8434. doi: 10.1038/s41467-024-52723-6 PMID: 39071328 Free PMC article. Updated. Preprint.

6

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.

Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z. Li X, et al. Among authors: zhang y. Nat Commun. 2024 Sep 29;15(1):8434. doi: 10.1038/s41467-024-52723-6. Nat Commun. 2024. PMID: 39343966 Free PMC article.

7

Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.

Pan PY, Sheehan P, Wang Q, Zhu X, Zhang Y, Choi I, Li X, Saenz J, Zhu J, Wang J, El Gaamouch F, Zhu L, Cai D, Yue Z. Pan PY, et al. Among authors: zhang y. Hum Mol Genet. 2020 Aug 11;29(14):2300-2312. doi: 10.1093/hmg/ddaa080. Hum Mol Genet. 2020. PMID: 32356558 Free PMC article.

8

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.

Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z. Choi I, et al. Among authors: zhang b, zhang y. Nat Commun. 2020 Mar 13;11(1):1386. doi: 10.1038/s41467-020-15119-w. Nat Commun. 2020. PMID: 32170061 Free PMC article.

9

Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.

Kearney PJ, Zhang Y, Liang M, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shaffer SA, Yue Z, Melikian HE. Kearney PJ, et al. Among authors: zhang y. NPJ Parkinsons Dis. 2024 Feb 23;10(1):41. doi: 10.1038/s41531-024-00648-8. NPJ Parkinsons Dis. 2024. PMID: 38395968 Free PMC article.

10

Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.

Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Lachance V, et al. Among authors: zhang b, zhang y. Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4. Mol Neurodegener. 2019. PMID: 31775806 Free PMC article.

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