Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod.
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J Hepatol. 2023 Jul;79(1):167-180. doi: 10.1016/j.jhep.2023.03.018. Epub 2023 Mar 28.
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PMID: 36996943