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MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation.
Guérin C, Vinchent A, Fernandes M, Damour I, Laratte A, Tellier R, Estevam GO, Meneboo JP, Villenet C, Descarpentries C, Fraser JS, Figeac M, Cortot AB, Rouleau E, Tulasne D. Guérin C, et al. Among authors: estevam go. bioRxiv [Preprint]. 2023 Nov 7:2023.11.03.565283. doi: 10.1101/2023.11.03.565283. bioRxiv. 2023. PMID: 37965202 Free PMC article. Preprint.
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS. Estevam GO, et al. bioRxiv [Preprint]. 2024 May 6:2023.08.03.551866. doi: 10.1101/2023.08.03.551866. bioRxiv. 2024. Update in: Elife. 2024 Sep 13;12:RP91619. doi: 10.7554/eLife.91619. PMID: 37577651 Free PMC article. Updated. Preprint.
State of the structure address on MET receptor activation by HGF.
Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N. Linossi EM, et al. Among authors: estevam go. Biochem Soc Trans. 2021 Apr 30;49(2):645-661. doi: 10.1042/BST20200394. Biochem Soc Trans. 2021. PMID: 33860789 Free PMC article. Review.