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Page 1
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S. Brina D, et al. Among authors: biffo s. Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261. Nat Commun. 2015. PMID: 26383020 Free PMC article.
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, Cirino D, Ricciardi S, Valenti L, Baselli G, D'Ambrosio R, Maggioni M, Brina D, Bresciani A, Biffo S. Scagliola A, et al. Among authors: biffo s. Nat Commun. 2021 Aug 12;12(1):4878. doi: 10.1038/s41467-021-25195-1. Nat Commun. 2021. PMID: 34385447 Free PMC article.
LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion.
Marasca F, Sinha S, Vadalà R, Polimeni B, Ranzani V, Paraboschi EM, Burattin FV, Ghilotti M, Crosti M, Negri ML, Campagnoli S, Notarbartolo S, Sartore-Bianchi A, Siena S, Prati D, Montini G, Viale G, Torre O, Harari S, Grifantini R, Soldà G, Biffo S, Abrignani S, Bodega B. Marasca F, et al. Among authors: biffo s. Nat Genet. 2022 Feb;54(2):180-193. doi: 10.1038/s41588-021-00989-7. Epub 2022 Jan 17. Nat Genet. 2022. PMID: 35039641
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M. Bonnal RJP, et al. Among authors: biffo s. Nat Immunol. 2021 Jun;22(6):735-745. doi: 10.1038/s41590-021-00930-4. Epub 2021 May 20. Nat Immunol. 2021. PMID: 34017124
The crosstalk between metabolism and translation.
Biffo S, Ruggero D, Santoro MM. Biffo S, et al. Cell Metab. 2024 Sep 3;36(9):1945-1962. doi: 10.1016/j.cmet.2024.07.022. Cell Metab. 2024. PMID: 39232280 Review.
110 results