Schulte G - Search Results

1

A molecular mechanism to diversify Ca²⁺ signaling downstream of Gs protein-coupled receptors.

Brands J, Bravo S, Jürgenliemke L, Grätz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, König G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E. Brands J, et al. Among authors: schulte g. Nat Commun. 2024 Sep 3;15(1):7684. doi: 10.1038/s41467-024-51991-6. Nat Commun. 2024. PMID: 39227390 Free PMC article.

2

WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins.

Bowin CF, Inoue A, Schulte G. Bowin CF, et al. Among authors: schulte g. J Biol Chem. 2019 Aug 2;294(31):11677-11684. doi: 10.1074/jbc.AC119.009412. Epub 2019 Jun 24. J Biol Chem. 2019. PMID: 31235524 Free PMC article.

3

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors.

Schihada H, Shekhani R, Schulte G. Schihada H, et al. Among authors: schulte g. Sci Signal. 2021 Sep 7;14(699):eabf1653. doi: 10.1126/scisignal.abf1653. Epub 2021 Sep 7. Sci Signal. 2021. PMID: 34516756

4

Residue 6.43 defines receptor function in class F GPCRs.

Turku A, Schihada H, Kozielewicz P, Bowin CF, Schulte G. Turku A, et al. Among authors: schulte g. Nat Commun. 2021 Jun 24;12(1):3919. doi: 10.1038/s41467-021-24004-z. Nat Commun. 2021. PMID: 34168128 Free PMC article.

5

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.

Bowin CF, Kozielewicz P, Grätz L, Kowalski-Jahn M, Schihada H, Schulte G. Bowin CF, et al. Among authors: schulte g. Sci Signal. 2023 Apr 4;16(779):eabo4974. doi: 10.1126/scisignal.abo4974. Epub 2023 Apr 4. Sci Signal. 2023. PMID: 37014927

6

Structural basis of frizzled 7 activation and allosteric regulation.

Bous J, Kinsolving J, Grätz L, Scharf MM, Voss JH, Selcuk B, Adebali O, Schulte G. Bous J, et al. Among authors: schulte g. Nat Commun. 2024 Aug 28;15(1):7422. doi: 10.1038/s41467-024-51664-4. Nat Commun. 2024. PMID: 39198452 Free PMC article.

7

FZD₁₀-Gα₁₃ signalling axis points to a role of FZD₁₀ in CNS angiogenesis.

Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G. Hot B, et al. Among authors: schulte g. Cell Signal. 2017 Apr;32:93-103. doi: 10.1016/j.cellsig.2017.01.023. Epub 2017 Jan 24. Cell Signal. 2017. PMID: 28126591

8

Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation.

Kozielewicz P, Schihada H, Schulte G. Kozielewicz P, et al. Among authors: schulte g. Handb Exp Pharmacol. 2021;269:101-115. doi: 10.1007/164_2021_534. Handb Exp Pharmacol. 2021. PMID: 34463848

9

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L, Kowalski-Jahn M, Scharf MM, Kozielewicz P, Jahn M, Bous J, Lambert NA, Gloriam DE, Schulte G. Grätz L, et al. Among authors: schulte g. Nat Commun. 2023 Jul 29;14(1):4573. doi: 10.1038/s41467-023-40213-0. Nat Commun. 2023. PMID: 37516754 Free PMC article.

10

Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs.

Grätz L, Voss JH, Schulte G. Grätz L, et al. Among authors: schulte g. ACS Sens. 2024 Aug 30. doi: 10.1021/acssensors.4c00806. Online ahead of print. ACS Sens. 2024. PMID: 39213612

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