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Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription.
Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353. Online ahead of print.
Anticancer Agents Med Chem. 2024.
PMID: 39225209
Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity.
Wagdy RA, Abutaleb NS, Fathalla RK, Elgammal Y, Weck S, Pal R, Fischer PD, Ducho C, Abadi AH, N Seleem M, Engel M, Abdel-Halim M.
Wagdy RA, et al. Among authors: fathalla rk.
Eur J Med Chem. 2023 Dec 5;261:115789. doi: 10.1016/j.ejmech.2023.115789. Epub 2023 Sep 4.
Eur J Med Chem. 2023.
PMID: 37717380
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Targeting the binding pocket of the fluorophore 8-anilinonaphthalene-1-sulfonic acid in the bacterial enzyme MurA.
Fathalla RK, Engel M, Ducho C.
Fathalla RK, et al.
Arch Pharm (Weinheim). 2023 Sep;356(9):e2300237. doi: 10.1002/ardp.202300237. Epub 2023 Jul 18.
Arch Pharm (Weinheim). 2023.
PMID: 37464574
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Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M.
Fathalla RK, et al.
J Med Chem. 2022 Nov 10;65(21):14740-14763. doi: 10.1021/acs.jmedchem.2c01275. Epub 2022 Oct 21.
J Med Chem. 2022.
PMID: 36269107
Free PMC article.
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Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria.
Fangary S, Abdel-Halim M, Fathalla RK, Hassan R, Farag N, Engel M, Mansour S, Tammam SN.
Fangary S, et al. Among authors: fathalla rk.
Mol Pharm. 2022 Sep 5;19(9):3163-3177. doi: 10.1021/acs.molpharmaceut.2c00258. Epub 2022 Jul 25.
Mol Pharm. 2022.
PMID: 35876358
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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Abdel-Halim M, Sigler S, Racheed NAS, Hefnawy A, Fathalla RK, Hammam MA, Maher A, Maxuitenko Y, Keeton AB, Hartmann RW, Engel M, Piazza GA, Abadi AH.
Abdel-Halim M, et al. Among authors: fathalla rk.
J Med Chem. 2021 Apr 22;64(8):4462-4477. doi: 10.1021/acs.jmedchem.0c01120. Epub 2021 Apr 1.
J Med Chem. 2021.
PMID: 33793216
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Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.
Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M.
Mokbel SA, et al. Among authors: fathalla rk.
Bioorg Chem. 2020 Jun;99:103759. doi: 10.1016/j.bioorg.2020.103759. Epub 2020 Mar 14.
Bioorg Chem. 2020.
PMID: 32220665
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