Engel M - Search Results

1

Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription.

Sigler S, Abdel-Halim M, Fathalla RK, Da Silva LM, Keeton AB, Maxuitenko YY, Berry K, Zhou G, Engel M, Abadi AH, Piazza GA. Sigler S, et al. Among authors: engel m. Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353. Online ahead of print. Anticancer Agents Med Chem. 2024. PMID: 39225209

2

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

El-Gamil DS, Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH. El-Gamil DS, et al. Among authors: engel m. Arch Pharm (Weinheim). 2013 Jan;346(1):23-33. doi: 10.1002/ardp.201200334. Arch Pharm (Weinheim). 2013. PMID: 23307609 Free PMC article.

3

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M. Hamed MM, et al. Among authors: engel m. ChemMedChem. 2013 Sep;8(9):1495-504. doi: 10.1002/cmdc.201300147. Epub 2013 Jul 11. ChemMedChem. 2013. PMID: 23847159

4

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Abdel-Halim M, et al. Among authors: engel m. Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1. Bioorg Med Chem. 2013. PMID: 24139845

5

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW, Engel M. Abdel-Halim M, et al. Among authors: engel m. J Med Chem. 2014 Aug 14;57(15):6513-30. doi: 10.1021/jm500521n. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25058929

6

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.

Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH. Rezk MS, et al. Among authors: engel m. Chem Pharm Bull (Tokyo). 2016;64(1):34-41. doi: 10.1248/cpb.c15-00608. Chem Pharm Bull (Tokyo). 2016. PMID: 26726742 Free article.

7

Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.

Ahmed NS, Elghazawy NH, ElHady AK, Engel M, Hartmann RW, Abadi AH. Ahmed NS, et al. Among authors: engel m. Eur J Med Chem. 2016 Apr 13;112:171-179. doi: 10.1016/j.ejmech.2016.02.026. Epub 2016 Feb 9. Eur J Med Chem. 2016. PMID: 26896706

8

Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M. Abdel-Halim M, et al. Among authors: engel m. Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016. Epub 2016 Aug 8. Eur J Pharm Sci. 2016. PMID: 27516147

9

First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents.

Hamed MM, Darwish SS, Herrmann J, Abadi AH, Engel M. Hamed MM, et al. Among authors: engel m. J Med Chem. 2017 Apr 13;60(7):2853-2868. doi: 10.1021/acs.jmedchem.6b01774. Epub 2017 Mar 28. J Med Chem. 2017. PMID: 28291344 Free article.

10

Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.

ElHady AK, Abdel-Halim M, Abadi AH, Engel M. ElHady AK, et al. Among authors: engel m. J Med Chem. 2017 Jul 13;60(13):5377-5391. doi: 10.1021/acs.jmedchem.6b01915. Epub 2017 May 31. J Med Chem. 2017. PMID: 28561591

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