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Page 1
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA. Mabanglo MF, et al. Among authors: barghash mm. Structure. 2023 Feb 2;31(2):185-200.e10. doi: 10.1016/j.str.2022.12.002. Epub 2022 Dec 30. Structure. 2023. PMID: 36586405 Free PMC article.
Cellular functions of the ClpP protease impacting bacterial virulence.
Aljghami ME, Barghash MM, Majaesic E, Bhandari V, Houry WA. Aljghami ME, et al. Among authors: barghash mm. Front Mol Biosci. 2022 Dec 1;9:1054408. doi: 10.3389/fmolb.2022.1054408. eCollection 2022. Front Mol Biosci. 2022. PMID: 36533084 Free PMC article. Review.
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice.
Ruiz-Riquelme A, Mao A, Barghash MM, Lau HHC, Stuart E, Kovacs GG, Nilsson KPR, Fraser PE, Schmitt-Ulms G, Watts JC. Ruiz-Riquelme A, et al. Among authors: barghash mm. Acta Neuropathol Commun. 2021 May 10;9(1):83. doi: 10.1186/s40478-021-01187-6. Acta Neuropathol Commun. 2021. PMID: 33971978 Free PMC article.
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.
Binepal G, Mabanglo MF, Goodreid JD, Leung E, Barghash MM, Wong KS, Lin F, Cossette M, Bansagi J, Song B, Balasco Serrão VH, Pai EF, Batey RA, Gray-Owen SD, Houry WA. Binepal G, et al. Among authors: barghash mm. ACS Infect Dis. 2020 Dec 11;6(12):3224-3236. doi: 10.1021/acsinfecdis.0c00599. Epub 2020 Nov 25. ACS Infect Dis. 2020. PMID: 33237740 Free PMC article.
ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.
Mabanglo MF, Leung E, Vahidi S, Seraphim TV, Eger BT, Bryson S, Bhandari V, Zhou JL, Mao YQ, Rizzolo K, Barghash MM, Goodreid JD, Phanse S, Babu M, Barbosa LRS, Ramos CHI, Batey RA, Kay LE, Pai EF, Houry WA. Mabanglo MF, et al. Among authors: barghash mm. Commun Biol. 2019 Nov 13;2:410. doi: 10.1038/s42003-019-0656-3. eCollection 2019. Commun Biol. 2019. PMID: 31754640 Free PMC article.