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A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders.
Gandhi PS, Zivkovic M, Østergaard H, Bonde AC, Elm T, Løvgreen MN, Schluckebier G, Johansson E, Olsen OH, Olsen EHN, de Bus IA, Bloem K, Alskär O, Rea CJ, Bjørn SE, Schutgens RE, Sørensen B, Urbanus RT, Faber JH. Gandhi PS, et al. Among authors: bonde ac. Nat Cardiovasc Res. 2024 Feb;3(2):166-185. doi: 10.1038/s44161-023-00418-4. Epub 2024 Feb 8. Nat Cardiovasc Res. 2024. PMID: 39196196 Free PMC article.
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, Johansson E, Røder G, Rasch MG, Johnsen LB, Egebjerg T, Lund S, Rahbek-Nielsen H, Gandhi PS, Lamberth K, Loftager M, Andersen LM, Bonde AC, Stavenuiter F, Madsen DE, Li X, Holm TL, Ley CD, Thygesen P, Zhu H, Zhou R, Thorn K, Yang Z, Hermit MB, Bjelke JR, Hansen BG, Hilden I. Østergaard H, et al. Among authors: bonde ac. Blood. 2021 Oct 7;138(14):1258-1268. doi: 10.1182/blood.2020010331. Blood. 2021. PMID: 34077951 Free PMC article.