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Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity.
Karamitros CS, Murray K, Winemiller B, Lamb C, Stone EM, D'Arcy S, Johnson KA, Georgiou G. Karamitros CS, et al. Among authors: johnson ka. Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2118979119. doi: 10.1073/pnas.2118979119. Epub 2022 Jun 3. Proc Natl Acad Sci U S A. 2022. PMID: 35658075 Free PMC article.
Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B, Lamb C, Tanno Y, Siddiqui MY, Ashoura N, Coma S, Zhang XM, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, Georgiou G. Blazeck J, et al. Among authors: johnson ka. Nat Catal. 2022 Oct;5(10):952-967. doi: 10.1038/s41929-022-00856-6. Epub 2022 Oct 19. Nat Catal. 2022. PMID: 36465553 Free PMC article.
Structural basis for mismatch surveillance by CRISPR-Cas9.
Bravo JPK, Liu MS, Hibshman GN, Dangerfield TL, Jung K, McCool RS, Johnson KA, Taylor DW. Bravo JPK, et al. Among authors: johnson ka. Nature. 2022 Mar;603(7900):343-347. doi: 10.1038/s41586-022-04470-1. Epub 2022 Mar 2. Nature. 2022. PMID: 35236982 Free PMC article.
1,882 results