Tang H - Search Results

1

Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation.

Zhang T, Pan Z, Gao J, Wu Q, Bai G, Li Y, Tong L, Feng F, Lai M, Liu Y, Song P, Ning Y, Tang H, Luo W, Chen Y, Fang Y, Zhang H, Liu Q, Zhang Y, Wang H, Chen Z, Chen Y, Geng M, Ji H, Zhao G, Zhou H, Ding J, Xie H. Zhang T, et al. Among authors: tang h. Signal Transduct Target Ther. 2024 Aug 15;9(1):216. doi: 10.1038/s41392-024-01928-8. Signal Transduct Target Ther. 2024. PMID: 39143065 Free PMC article.

2

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: tang h. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

3

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK.

Song P, Bai G, Chan S, Zhang T, Tong L, Su Y, Shen Y, Chen Y, Liu Y, Lai M, Ning Y, Tang H, Fang Y, Chen Y, Ding K, Ding J, Xie H. Song P, et al. Among authors: tang h. Front Pharmacol. 2022 Dec 15;13:1071114. doi: 10.3389/fphar.2022.1071114. eCollection 2022. Front Pharmacol. 2022. PMID: 36588692 Free PMC article.

4

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo.

Lai M, Zhang T, Chen H, Song P, Tong L, Chen J, Liu Y, Ning Y, Feng F, Li Y, Tang H, Chen Y, Fang Y, Lu X, Geng M, Ding K, Yu K, Ding J, Xie H. Lai M, et al. Among authors: tang h. J Cancer. 2023 Jan 1;14(1):152-162. doi: 10.7150/jca.77788. eCollection 2023. J Cancer. 2023. PMID: 36605493 Free PMC article.

5

Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors.

Zhang J, Li Y, Tang H, Zhou Q, Tong L, Ding J, Xie H, Xiong B, Liu T. Zhang J, et al. Among authors: tang h. Bioorg Chem. 2023 Nov;140:106811. doi: 10.1016/j.bioorg.2023.106811. Epub 2023 Aug 26. Bioorg Chem. 2023. PMID: 37659145

6

A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy.

Liu Y, Tong L, Zhang M, Zhang Q, Liu Q, Feng F, Li Y, Lai M, Tang H, Chen Y, Geng M, Duan W, Ding J, Xie H. Liu Y, et al. Among authors: tang h. Cancer Commun (Lond). 2024 Mar;44(3):438-442. doi: 10.1002/cac2.12521. Epub 2024 Feb 9. Cancer Commun (Lond). 2024. PMID: 38335159 Free PMC article. No abstract available.

7

A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease.

Huang Y, Ning Y, Chen Z, Song P, Tang H, Shi W, Wan Z, Huang G, Liu Q, Chen Y, Zhou Y, Li Y, Zhan Z, Ding J, Duan W, Xie H. Huang Y, et al. Among authors: tang h. Molecules. 2024 Apr 16;29(8):1803. doi: 10.3390/molecules29081803. Molecules. 2024. PMID: 38675622 Free PMC article.

8

Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas.

Song PR, Wan ZP, Huang GG, Song ZL, Zhang T, Tong LJ, Fang Y, Tang HT, Xue Y, Zhan ZS, Feng F, Li Y, Shi WH, Huang YQ, Chen Y, Duan WH, Ding J, Zhang A, Xie H. Song PR, et al. Among authors: tang ht. Acta Pharmacol Sin. 2024 Oct;45(10):2163-2173. doi: 10.1038/s41401-024-01311-x. Epub 2024 Jun 4. Acta Pharmacol Sin. 2024. PMID: 38834683

9

Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors.

Song S, Tang H, Ran T, Fang F, Tong L, Chen H, Xie H, Lu X. Song S, et al. Among authors: tang h. Eur J Med Chem. 2023 Feb 5;247:115034. doi: 10.1016/j.ejmech.2022.115034. Epub 2022 Dec 22. Eur J Med Chem. 2023. PMID: 36603506

10

Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.

Lou J, Zhou Q, Lyu X, Cen X, Liu C, Yan Z, Li Y, Tang H, Liu Q, Ding J, Lu Y, Huang H, Xie H, Zhao Y. Lou J, et al. Among authors: tang h. J Med Chem. 2024 Jul 11;67(13):10795-10830. doi: 10.1021/acs.jmedchem.4c00291. Epub 2024 Jun 24. J Med Chem. 2024. PMID: 38913996

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