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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Profaci CP, et al. Among authors: longworth a. Neuron. 2024 Sep 4;112(17):2910-2921.e7. doi: 10.1016/j.neuron.2024.07.015. Epub 2024 Aug 13. Neuron. 2024. PMID: 39142282 Free article.
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis.
Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. Evans KT, et al. Among authors: longworth a. Nat Cell Biol. 2023 Dec;25(12):1848-1859. doi: 10.1038/s41556-023-01273-y. Epub 2023 Nov 13. Nat Cell Biol. 2023. PMID: 37957324 Free PMC article.
21 results