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Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.
Räsänen J, Heikkinen S, Mäklin K, Lipponen A, Kuulasmaa T, Mehtonen J, Korhonen VE, Junkkari A, Grenier-Boley B, Bellenguez C, Oinas M, Avellan C, Frantzén J, Kotkansalo A, Rinne J, Ronkainen A, Kauppinen M, von Und Zu Fraunberg M, Lönnrot K, Satopää J, Perola M, Koivisto AM, Julkunen V, Portaankorva AM, Mannermaa A, Soininen H, Helisalmi S, Jääskeläinen JE, Lambert JC, Eide PK; for FinnGen; Palotie A, Kurki MI, Hiltunen M, Leinonen V. Räsänen J, et al. Among authors: maklin k. Neurology. 2024 Sep 10;103(5):e209694. doi: 10.1212/WNL.0000000000209694. Epub 2024 Aug 14. Neurology. 2024. PMID: 39141892 Free PMC article.
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Selvarajan I, Kiema M, Huang RT, Li J, Zhu J, Pölönen P, Örd T, Õunap K, Godiwala M, Golebiewski AK, Ravindran A, Mäklin K, Toropainen A, Stolze LK, Arce M, Magnusson PU, White S, Romanoski CE, Heinäniemi M, Laakkonen JP, Fang Y, Kaikkonen MU. Selvarajan I, et al. Among authors: maklin k. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1330-1345. doi: 10.1161/ATVBAHA.123.318964. Epub 2024 Apr 11. Arterioscler Thromb Vasc Biol. 2024. PMID: 38602103 Free article.
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells.
Singha PK, Mäklin K, Vihavainen T, Laitinen T, Nevalainen TJ, Patil MR, Tonduru AK, Poso A, Laitinen JT, Savinainen JR. Singha PK, et al. Among authors: maklin k. Eur J Pharm Sci. 2020 Apr 7;149:105321. doi: 10.1016/j.ejps.2020.105321. Online ahead of print. Eur J Pharm Sci. 2020. PMID: 32275951