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Page 1
Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.
Marquart KF, Mathis N, Mollaysa A, Müller S, Kissling L, Rothgangl T, Schmidheini L, Kulcsár PI, Allam A, Kaufmann MM, Matsushita M, Haenggi T, Cathomen T, Kopf M, Krauthammer M, Schwank G. Marquart KF, et al. Among authors: schmidheini l. Nat Methods. 2024 Nov;21(11):2084-2093. doi: 10.1038/s41592-024-02418-z. Epub 2024 Sep 23. Nat Methods. 2024. PMID: 39313558
Publisher Correction: Machine learning prediction of prime editing efficiency across diverse chromatin contexts.
Mathis N, Allam A, Tálas A, Kissling L, Benvenuto E, Schmidheini L, Schep R, Damodharan T, Balázs Z, Janjuha S, Ioannidi EI, Böck D, van Steensel B, Krauthammer M, Schwank G. Mathis N, et al. Among authors: schmidheini l. Nat Biotechnol. 2024 Aug 12. doi: 10.1038/s41587-024-02383-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 39134755 No abstract available.
Machine learning prediction of prime editing efficiency across diverse chromatin contexts.
Mathis N, Allam A, Tálas A, Kissling L, Benvenuto E, Schmidheini L, Schep R, Damodharan T, Balázs Z, Janjuha S, Ioannidi EI, Böck D, van Steensel B, Krauthammer M, Schwank G. Mathis N, et al. Among authors: schmidheini l. Nat Biotechnol. 2024 Jun 21. doi: 10.1038/s41587-024-02268-2. Online ahead of print. Nat Biotechnol. 2024. PMID: 38907037
Predicting prime editing efficiency and product purity by deep learning.
Mathis N, Allam A, Kissling L, Marquart KF, Schmidheini L, Solari C, Balázs Z, Krauthammer M, Schwank G. Mathis N, et al. Among authors: schmidheini l. Nat Biotechnol. 2023 Aug;41(8):1151-1159. doi: 10.1038/s41587-022-01613-7. Epub 2023 Jan 16. Nat Biotechnol. 2023. PMID: 36646933 Free PMC article.
In vivo prime editing of a metabolic liver disease in mice.
Böck D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thöny B, Schwank G. Böck D, et al. Among authors: schmidheini l. Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16. Sci Transl Med. 2022. PMID: 35294257 Free PMC article.