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PITX2 deficiency leads to atrial mitochondrial dysfunction.
Reyat JS, Sommerfeld LC, O'Reilly M, Cardoso VR, Thiemann E, Khan AO, O'Shea C, Harder S, Müller C, Barlow J, Stapley RJ, Chua W, Kabir SN, Grech O, Hummel O, Hübner N, Kääb S, Mont L, Hatem SN, Winters J, Zeemering S, Morgan NV, Rayes J, Gehmlich K, Stoll M, Brand T, Schweizer M, Piasecki A, Schotten U, Gkoutos GV, Lorenz K, Cuello F, Kirchhof P, Fabritz L. Reyat JS, et al. Cardiovasc Res. 2024 Aug 12:cvae169. doi: 10.1093/cvr/cvae169. Online ahead of print. Cardiovasc Res. 2024. PMID: 39129206
Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide.
O'Reilly M, Sommerfeld LC, O'Shea C, Broadway-Stringer S, Andaleeb S, Reyat JS, Kabir SN, Stastny D, Malinova A, Delbue D, Fortmueller L, Gehmlich K, Pavlovic D, Skryabin BV, Holmes AP, Kirchhof P, Fabritz L. O'Reilly M, et al. Europace. 2023 Mar 30;25(3):1152-1161. doi: 10.1093/europace/euac218. Europace. 2023. PMID: 36504385 Free PMC article.
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse.
Sommerfeld LC, Holmes AP, Yu TY, O'Shea C, Kavanagh DM, Pike JM, Wright T, Syeda F, Aljehani A, Kew T, Cardoso VR, Kabir SN, Hepburn C, Menon PR, Broadway-Stringer S, O'Reilly M, Witten A, Fortmueller L, Lutz S, Kulle A, Gkoutos GV, Pavlovic D, Arlt W, Lavery GG, Steeds R, Gehmlich K, Stoll M, Kirchhof P, Fabritz L. Sommerfeld LC, et al. J Physiol. 2024 Sep;602(18):4409-4436. doi: 10.1113/JP284597. Epub 2024 Feb 12. J Physiol. 2024. PMID: 38345865
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek MS, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M, Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O'Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A. Künzel SR, et al. Circ Res. 2021 Oct;129(8):804-820. doi: 10.1161/CIRCRESAHA.121.319425. Epub 2021 Aug 26. Circ Res. 2021. PMID: 34433292 Free PMC article.
1,614 results