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The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation.
Kato Y, Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M. Kato Y, et al. Among authors: hara yokoyama m. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126891. doi: 10.1016/j.bmcl.2019.126891. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31874824
Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells.
Terasawa K, Kato Y, Ikami Y, Sakamoto K, Ohtake K, Kusano S, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Guan JL, Kobayashi T, Iwata T, Watabe T, Yokoyama S, Hara-Yokoyama M. Terasawa K, et al. Among authors: hara yokoyama m. Autophagy. 2021 Dec;17(12):4286-4304. doi: 10.1080/15548627.2021.1911017. Epub 2021 Apr 14. Autophagy. 2021. PMID: 33849387 Free PMC article.
The two-domain architecture of LAMP2A regulates its interaction with Hsc70.
Ikami Y, Terasawa K, Sakamoto K, Ohtake K, Harada H, Watabe T, Yokoyama S, Hara-Yokoyama M. Ikami Y, et al. Among authors: hara yokoyama m. Exp Cell Res. 2022 Feb 1;411(1):112986. doi: 10.1016/j.yexcr.2021.112986. Epub 2021 Dec 21. Exp Cell Res. 2022. PMID: 34942188
Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M. Hara-Yokoyama M, et al. Structure. 2012 Sep 5;20(9):1585-95. doi: 10.1016/j.str.2012.06.017. Epub 2012 Aug 2. Structure. 2012. PMID: 22863568 Free article.
52 results