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Page 1
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease.
Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips J, Iturbe A, Erquizi A, Moore BD, Ryu D, Natu A, Dillon K, Torrellas J, Moran C, Ladd T, Afroz F, Islam T, Jagirdar J, Funk CC, Robinson M, Rangaraju S, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson ECB, McFarland K, Levey AI, Prokop S, Seyfried NT, Golde TE. Levites Y, et al. Among authors: ladd t. Cell Rep Med. 2024 Aug 20;5(8):101669. doi: 10.1016/j.xcrm.2024.101669. Epub 2024 Aug 9. Cell Rep Med. 2024. PMID: 39127040 Free PMC article.
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, Moore BD, Liu X, Ceballos-Diaz C, Rosario AM, Medway C, Janus C, Li HD, Dickson DW, Giasson BI, Price ND, Younkin SG, Ertekin-Taner N, Golde TE. Chakrabarty P, et al. J Exp Med. 2018 Sep 3;215(9):2247-2264. doi: 10.1084/jem.20180484. J Exp Med. 2018. PMID: 30158114 Free PMC article.
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE. Moore BD, et al. J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5. J Exp Med. 2018. PMID: 29208777 Free PMC article.
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.
Levites Y, Funk C, Wang X, Chakrabarty P, McFarland KN, Bramblett B, O'Neal V, Liu X, Ladd T, Robinson M, Allen M, Carrasquillo MM, Dickson D, Cruz P, Ryu D, Li HD, Price ND, Ertekin-Taner N, Golde TE. Levites Y, et al. Among authors: ladd t. Mol Neurodegener. 2021 May 6;16(1):32. doi: 10.1186/s13024-021-00453-4. Mol Neurodegener. 2021. PMID: 33957936 Free PMC article.
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo.
McFarland KN, Ceballos C, Rosario A, Ladd T, Moore B, Golde G, Wang X, Allen M, Ertekin-Taner N, Funk CC, Robinson M, Baloni P, Rappaport N, Chakrabarty P, Golde TE. McFarland KN, et al. Among authors: ladd t. Life Sci Alliance. 2021 Jun 14;4(7):e202101108. doi: 10.26508/lsa.202101108. Print 2021 Jul. Life Sci Alliance. 2021. PMID: 34127518 Free PMC article.
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.
Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, Dillon KD, Torrellas J, Moran C, Ladd TB, Afroz KF, Islam T, Jagirdar J, Funk CC, Robinson M, Borchelt DR, Ertekin-Taner N, Kelly JW, Heppner FL, Johnson EC, McFarland K, Levey AL, Prokop S, Seyfried NT, Golde TE. Levites Y, et al. Among authors: ladd tb. bioRxiv [Preprint]. 2023 Dec 7:2023.11.29.568318. doi: 10.1101/2023.11.29.568318. bioRxiv. 2023. Update in: Cell Rep Med. 2024 Aug 20;5(8):101669. doi: 10.1016/j.xcrm.2024.101669 PMID: 38076912 Free PMC article. Updated. Preprint.
Designing antibodies against LRRK2-targeted tau epitopes.
Hamm M, Ladd TB, Levites Y, Golde TE, Giasson BI, Lewis J. Hamm M, et al. PLoS One. 2018 Sep 27;13(9):e0204367. doi: 10.1371/journal.pone.0204367. eCollection 2018. PLoS One. 2018. PMID: 30261006 Free PMC article.
APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. Deyts C, et al. Among authors: ladd tb. Cell Rep. 2019 Apr 30;27(5):1345-1355.e6. doi: 10.1016/j.celrep.2019.03.087. Cell Rep. 2019. PMID: 31042463 Free PMC article.
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE. Futch HS, et al. J Exp Med. 2019 Nov 4;216(11):2479-2491. doi: 10.1084/jem.20190430. Epub 2019 Aug 29. J Exp Med. 2019. PMID: 31467037 Free PMC article.
97 results