Coughlan KA - Search Results

1

Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy.

Coughlan KA, Eybye M, Henderson N, DeAntonis CM, Frassetto A, Hanahoe E, Ketova T, Jacquinet E, Presnyak V, Jain R, Marshall J, Martini PGV. Coughlan KA, et al. Mol Genet Metab. 2024 Aug 5;143(1-2):108560. doi: 10.1016/j.ymgme.2024.108560. Online ahead of print. Mol Genet Metab. 2024. PMID: 39121792

2

Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model.

Zhao XJ, Mohsen AW, Mihalik S, Solo K, Aliu E, Shi H, Basu S, Kochersperger C, Van't Land C, Karunanidhi A, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: coughlan ka. Mol Genet Metab. 2023 Jan;138(1):106982. doi: 10.1016/j.ymgme.2022.106982. Epub 2022 Dec 23. Mol Genet Metab. 2023. PMID: 36580829 Free PMC article.

3

Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model.

Zhao XJ, Mohsen AW, Mihalik S, Solo K, Basu S, Aliu E, Shi H, Kochersberger C, Karunanidhi A, Van't Land C, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, DeAntonis C, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: coughlan ka. Hum Mol Genet. 2023 Jul 4;32(14):2347-2356. doi: 10.1093/hmg/ddad076. Hum Mol Genet. 2023. PMID: 37162351 Free PMC article.

4

Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria.

Baek R, Coughlan K, Jiang L, Liang M, Ci L, Singh H, Zhang H, Kaushal N, Rajlic IL, Van L, Dimen R, Cavedon A, Yin L, Rice L, Frassetto A, Guey L, Finn P, Martini PGV. Baek R, et al. Nat Commun. 2024 May 7;15(1):3804. doi: 10.1038/s41467-024-47460-9. Nat Commun. 2024. PMID: 38714648 Free PMC article.

5

Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model.

Greig JA, Chorazeczewski JK, Chowdhary V, Smith MK, Jennis M, Tarrant JC, Buza EL, Coughlan K, Martini PGV, Wilson JM. Greig JA, et al. Mol Ther Methods Clin Dev. 2023 Feb 15;29:32-39. doi: 10.1016/j.omtm.2023.02.007. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 36936447 Free PMC article.

6

Lipid Nanoparticle mRNA Therapy Improves Survival and Reduces Serum Branched-Chain Amino Acids in Mouse Models of Maple Syrup Urine Disease.

Greig JA, Jennis M, Dandekar A, Chorazeczewski JK, Param N, So M, Nayal M, Bell P, Coughlan K, Choi M, Giangrande PH, Martini PGV, Wilson JM. Greig JA, et al. Hum Gene Ther. 2024 Sep;35(17-18):726-733. doi: 10.1089/hum.2024.047. Epub 2024 Aug 5. Hum Gene Ther. 2024. PMID: 39001827 No abstract available.

7

Loss of AMPKalpha1 Triggers Centrosome Amplification via PLK4 Upregulation in Mouse Embryonic Fibroblasts.

Zhao Q, Coughlan KA, Zou MH, Song P. Zhao Q, et al. Among authors: coughlan ka. Int J Mol Sci. 2020 Apr 16;21(8):2772. doi: 10.3390/ijms21082772. Int J Mol Sci. 2020. PMID: 32316320 Free PMC article.

8

Correction: Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.

Okon IS, Coughlan KA, Zou MH. Okon IS, et al. Among authors: coughlan ka. J Biol Chem. 2019 Aug 16;294(33):12555. doi: 10.1074/jbc.AAC119.010208. J Biol Chem. 2019. PMID: 31420522 Free PMC article. No abstract available.

9

The effects of troglitazone on AMPK in HepG2 cells.

Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. Allen KM, et al. Among authors: coughlan ka. Arch Biochem Biophys. 2017 Jun 1;623-624:49-57. doi: 10.1016/j.abb.2017.05.010. Epub 2017 May 16. Arch Biochem Biophys. 2017. PMID: 28526426

10

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. Coughlan KA, et al. J Biol Chem. 2016 Mar 11;291(11):5664-5675. doi: 10.1074/jbc.M115.696849. Epub 2016 Jan 21. J Biol Chem. 2016. PMID: 26797128 Free PMC article.

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