Liu YL - Search Results

1

Recent contributions of pyridazine as a privileged scaffold of anticancer agents in medicinal chemistry: An updated review.

Liu ZQ, Zhang Q, Liu YL, Yu XQ, Chui RH, Zhang LL, Zhao B, Ma LY. Liu ZQ, et al. Among authors: liu yl. Bioorg Med Chem. 2024 Sep 1;111:117847. doi: 10.1016/j.bmc.2024.117847. Epub 2024 Jul 28. Bioorg Med Chem. 2024. PMID: 39121679 Review.

2

Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates.

Wu H, Li X, He C, Liu Y, Wang C, Yang X, Ma F, Liu J, Xu J. Wu H, et al. Bioorg Med Chem. 2022 Jun 15;64:116776. doi: 10.1016/j.bmc.2022.116776. Epub 2022 Apr 25. Bioorg Med Chem. 2022. PMID: 35483137

3

Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.

Wang Y, Liu Y, Zhang Y, Zhang Z, Xu L, Wang J, Yang Y, Hu B, Yao Y, Wei M, Wang J, Tang B, Zhang K, Liu S, Yang G. Wang Y, et al. Eur J Med Chem. 2024 May 5;271:116395. doi: 10.1016/j.ejmech.2024.116395. Epub 2024 Apr 12. Eur J Med Chem. 2024. PMID: 38626523

4

Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).

Xie S, Sun Y, Liu Y, Li X, Li X, Zhong W, Zhan F, Zhu J, Yao H, Yang DH, Chen ZS, Xu J, Xu S. Xie S, et al. J Med Chem. 2021 Jul 8;64(13):9120-9140. doi: 10.1021/acs.jmedchem.1c00270. Epub 2021 Jun 28. J Med Chem. 2021. PMID: 34176264

5

Discovery of novel and bioavailable histone deacetylases and cyclin-dependent kinases dual inhibitor to impair the stemness of leukemia cells.

Liu Y, Wei Y, Wang X, Ma L, Li X, Sun Y, Wu Y, Zhang L, Wang J, Li M, Zhang K, Wei M, Yang G, Yang C. Liu Y, et al. Eur J Med Chem. 2023 Mar 5;249:115140. doi: 10.1016/j.ejmech.2023.115140. Epub 2023 Jan 21. Eur J Med Chem. 2023. PMID: 36736154

6

First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo.

Wei M, Zhao R, Cao Y, Wei Y, Li M, Dong Z, Liu Y, Ruan H, Li Y, Cao S, Tang Z, Zhou Y, Song W, Wang Y, Wang J, Yang G, Yang C. Wei M, et al. Eur J Med Chem. 2021 Jan 1;209:112903. doi: 10.1016/j.ejmech.2020.112903. Epub 2020 Oct 9. Eur J Med Chem. 2021. PMID: 33256948

7

Discovery and Optimization of a Novel 2H-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor.

Wei Y, Tang Y, Zhou Y, Yang Y, Cui Y, Wang X, Wang Y, Liu Y, Liu N, Wang Q, Li C, Ruan H, Zhou H, Wei M, Yang G, Yang C. Wei Y, et al. J Med Chem. 2021 Jul 8;64(13):9078-9099. doi: 10.1021/acs.jmedchem.1c00174. Epub 2021 Jun 15. J Med Chem. 2021. PMID: 34129329

8

Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells.

Cao S, Ma L, Liu Y, Wei M, Yao Y, Li C, Wang R, Liu N, Dong Z, Li X, Li M, Wang X, Yang C, Yang G. Cao S, et al. J Med Chem. 2021 Nov 25;64(22):16497-16511. doi: 10.1021/acs.jmedchem.1c00996. Epub 2021 Oct 25. J Med Chem. 2021. PMID: 34694800

9

5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2.

Wei M, Zhou Y, Li C, Yang Y, Liu T, Liu Y, Wei Y, Liu N, Liu S, Wang Q, Cao S, Sun Y, Sheng P, Lu C, Yang C, Liu X, Yang G. Wei M, et al. J Med Chem. 2021 Sep 9;64(17):12537-12547. doi: 10.1021/acs.jmedchem.1c00267. Epub 2021 Aug 5. J Med Chem. 2021. PMID: 34351142

10

Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.

Liu Y, Uras G, Onuwaje I, Li W, Yao H, Xu S, Li X, Li X, Phillips J, Allen S, Gong Q, Zhang H, Zhu Z, Liu J, Xu J. Liu Y, et al. Eur J Med Chem. 2022 May 5;235:114305. doi: 10.1016/j.ejmech.2022.114305. Epub 2022 Mar 18. Eur J Med Chem. 2022. PMID: 35339839

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