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Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers.
Loi P, Schade AE, Rodriguez CL, Krishnan A, Perurena N, Nguyen VTM, Xu Y, Watanabe M, Davis RA, Gardner A, Pilla NF, Mattioli K, Popow O, Gunduz N, Lannagan TRM, Fitzgerald S, Sicinska ET, Lin JR, Tan W, Brais LK, Haigis KM, Giannakis M, Ng K, Santagata S, Helin K, Sansom OJ, Cichowski K. Loi P, et al. Among authors: perurena n. Cancer Discov. 2024 Aug 12. doi: 10.1158/2159-8290.CD-23-0866. Online ahead of print. Cancer Discov. 2024. PMID: 39121480
Combinatorial strategies to target RAS-driven cancers.
Perurena N, Situ L, Cichowski K. Perurena N, et al. Nat Rev Cancer. 2024 May;24(5):316-337. doi: 10.1038/s41568-024-00679-6. Epub 2024 Apr 16. Nat Rev Cancer. 2024. PMID: 38627557 Review.
USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.
Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, Hahn WC, Morton JP, Sansom OJ, Aguirre AJ, Cichowski K. Perurena N, et al. Cell Rep Med. 2023 Apr 18;4(4):101007. doi: 10.1016/j.xcrm.2023.101007. Epub 2023 Apr 7. Cell Rep Med. 2023. PMID: 37030295 Free PMC article.
Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer.
Ruiz-Fernández de Córdoba B, Moreno H, Valencia K, Perurena N, Ruedas P, Walle T, Pezonaga-Torres A, Hinojosa J, Guruceaga E, Pineda-Lucena A, Abengózar-Muela M, Cochonneau D, Zandueta C, Martínez-Canarias S, Teijeira Á, Ajona D, Ortiz-Espinosa S, Morales X, Ortiz de Solórzano C, Santisteban M, Ramos-García LI, Guembe L, Strnad V, Heymann D, Hervás-Stubbs S, Pío R, Rodríguez-Ruiz ME, de Andrea CE, Vicent S, Melero I, Lecanda F, Martínez-Monge R. Ruiz-Fernández de Córdoba B, et al. Among authors: perurena n. Cancer Discov. 2022 May 2;12(5):1356-1377. doi: 10.1158/2159-8290.CD-21-0932. Cancer Discov. 2022. PMID: 35191482 Free PMC article.
Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects.
Ajona D, Zandueta C, Corrales L, Moreno H, Pajares MJ, Ortiz-Espinosa S, Martínez-Terroba E, Perurena N, de Miguel FJ, Jantus-Lewintre E, Camps C, Vicent S, Agorreta J, Montuenga LM, Pio R, Lecanda F. Ajona D, et al. Among authors: perurena n. Am J Respir Crit Care Med. 2018 May 1;197(9):1164-1176. doi: 10.1164/rccm.201703-0660OC. Am J Respir Crit Care Med. 2018. PMID: 29327939 Free PMC article.
An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S. Vallejo A, et al. Among authors: perurena n. Nat Commun. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294. Nat Commun. 2017. PMID: 28220783 Free PMC article.
17 results