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Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines.
Calderón-Arancibia J, Espinosa-Bustos C, Cañete-Molina Á, Tapia RA, Faúndez M, Torres MJ, Aguirre A, Paulino M, Salas CO. Calderón-Arancibia J, et al. Among authors: salas co. Molecules. 2015 Apr 15;20(4):6808-26. doi: 10.3390/molecules20046808. Molecules. 2015. PMID: 25884555 Free PMC article.
A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo.
Zárate AM, Espinosa-Bustos C, Guerrero S, Fierro A, Oyarzún-Ampuero F, Quest AFG, Di Marcotullio L, Loricchio E, Caimano M, Calcaterra A, González-Quiroz M, Aguirre A, Meléndez J, Salas CO. Zárate AM, et al. Among authors: salas co. Int J Mol Sci. 2021 Aug 4;22(16):8372. doi: 10.3390/ijms22168372. Int J Mol Sci. 2021. PMID: 34445078 Free PMC article.
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia.
Bertrand J, Dostálová H, Kryštof V, Jorda R, Delgado T, Castro-Alvarez A, Mella J, Cabezas D, Faúndez M, Espinosa-Bustos C, Salas CO. Bertrand J, et al. Among authors: salas co. Pharmaceutics. 2022 Jun 17;14(6):1294. doi: 10.3390/pharmaceutics14061294. Pharmaceutics. 2022. PMID: 35745866 Free PMC article.
48 results