Dohlman HG - Search Results

1

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.

Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: dohlman hg. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.

2

A universal allosteric mechanism for G protein activation.

Knight KM, Ghosh S, Campbell SL, Lefevre TJ, Olsen RHJ, Smrcka AV, Valentin NH, Yin G, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: dohlman hg. Mol Cell. 2021 Apr 1;81(7):1384-1396.e6. doi: 10.1016/j.molcel.2021.02.002. Epub 2021 Feb 25. Mol Cell. 2021. PMID: 33636126 Free PMC article.

3

Catalytic site mutations confer multiple states of G protein activation.

Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG. Hewitt N, et al. Among authors: dohlman hg. Sci Signal. 2023 Feb 14;16(772):eabq7842. doi: 10.1126/scisignal.abq7842. Epub 2023 Feb 14. Sci Signal. 2023. PMID: 36787384 Free PMC article.

4

Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast.

Isom DG, Page SC, Collins LB, Kapolka NJ, Taghon GJ, Dohlman HG. Isom DG, et al. Among authors: dohlman hg. J Biol Chem. 2018 Feb 16;293(7):2318-2329. doi: 10.1074/jbc.RA117.000422. Epub 2017 Dec 28. J Biol Chem. 2018. PMID: 29284676 Free PMC article.

5

Diminishing returns.

Dohlman HG. Dohlman HG. Nature. 2002 Aug 8;418(6898):591. doi: 10.1038/418591a. Nature. 2002. PMID: 12167838 No abstract available.

6

Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana.

Jones JC, Temple BR, Jones AM, Dohlman HG. Jones JC, et al. Among authors: dohlman hg. J Biol Chem. 2011 Apr 15;286(15):13143-50. doi: 10.1074/jbc.M110.190355. Epub 2011 Feb 16. J Biol Chem. 2011. PMID: 21325279 Free PMC article.

7

The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.

Jones JC, Duffy JW, Machius M, Temple BR, Dohlman HG, Jones AM. Jones JC, et al. Among authors: dohlman hg. Sci Signal. 2011 Feb 8;4(159):ra8. doi: 10.1126/scisignal.2001446. Sci Signal. 2011. PMID: 21304159 Free PMC article.

8

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

Jones JC, Jones AM, Temple BR, Dohlman HG. Jones JC, et al. Among authors: dohlman hg. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7275-9. doi: 10.1073/pnas.1202943109. Epub 2012 Apr 23. Proc Natl Acad Sci U S A. 2012. PMID: 22529365 Free PMC article.

9

Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit.

Wu YL, Hooks SB, Harden TK, Dohlman HG. Wu YL, et al. Among authors: dohlman hg. J Biol Chem. 2004 Aug 20;279(34):35287-97. doi: 10.1074/jbc.M404896200. Epub 2004 Jun 14. J Biol Chem. 2004. PMID: 15197187 Free article.

10

A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.

Lan KL, Sarvazyan NA, Taussig R, Mackenzie RG, DiBello PR, Dohlman HG, Neubig RR. Lan KL, et al. Among authors: dohlman hg. J Biol Chem. 1998 May 22;273(21):12794-7. doi: 10.1074/jbc.273.21.12794. J Biol Chem. 1998. PMID: 9582306 Free article.

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