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Computationally designed mRNA-launched protein nanoparticle vaccines.
Hendricks GG, Grigoryan L, Navarro MJ, Catanzaro NJ, Hubbard ML, Powers JM, Mattocks M, Treichel C, Walls AC, Lee J, Ellis D, Wang JYJ, Cheng S, Miranda MC, Valdez A, Chao CW, Chan S, Men C, Johnson MR, Hui H, Wu SY, Lujan V, Muramatsu H, Lin PJC, Sung MMH, Tam YK, Leaf EM, Pardi N, Baric RS, Pulendran B, Veesler D, Schäfer A, King NP. Hendricks GG, et al. Among authors: leaf em. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604655. doi: 10.1101/2024.07.22.604655. bioRxiv. 2024. PMID: 39091730 Free PMC article. Preprint.
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.
Chao CW, Sprouse KR, Miranda MC, Catanzaro NJ, Hubbard ML, Addetia A, Stewart C, Brown JT, Dosey A, Valdez A, Ravichandran R, Hendricks GG, Ahlrichs M, Dobbins C, Hand A, Treichel C, Willoughby I, Walls AC, McGuire AT, Leaf EM, Baric RS, Schäfer A, Veesler D, King NP. Chao CW, et al. Among authors: leaf em. bioRxiv [Preprint]. 2024 Mar 14:2024.03.13.584735. doi: 10.1101/2024.03.13.584735. bioRxiv. 2024. PMID: 38558973 Free PMC article. Preprint.
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.
Lee J, Stewart C, Schaefer A, Leaf EM, Park YJ, Asarnow D, Powers JM, Treichel C, Corti D, Baric R, King NP, Veesler D. Lee J, et al. Among authors: leaf em. bioRxiv [Preprint]. 2023 Dec 20:2023.12.12.571160. doi: 10.1101/2023.12.12.571160. bioRxiv. 2023. Update in: Nat Commun. 2024 Jun 28;15(1):5496. doi: 10.1038/s41467-024-49656-5 PMID: 38168207 Free PMC article. Updated. Preprint.
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus.
Lee J, Zepeda SK, Park YJ, Taylor AL, Quispe J, Stewart C, Leaf EM, Treichel C, Corti D, King NP, Starr TN, Veesler D. Lee J, et al. Among authors: leaf em. Cell Host Microbe. 2023 Dec 13;31(12):1961-1973.e11. doi: 10.1016/j.chom.2023.10.018. Epub 2023 Nov 20. Cell Host Microbe. 2023. PMID: 37989312 Free article.
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus.
Lee J, Zepeda SK, Park YJ, Taylor AL, Quispe J, Stewart C, Leaf EM, Treichel C, Corti D, King NP, Starr TN, Veesler D. Lee J, et al. Among authors: leaf em. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557371. doi: 10.1101/2023.09.12.557371. bioRxiv. 2023. Update in: Cell Host Microbe. 2023 Dec 13;31(12):1961-1973.e11. doi: 10.1016/j.chom.2023.10.018 PMID: 37745523 Free PMC article. Updated. Preprint.
Top-down design of protein architectures with reinforcement learning.
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sánchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D. Lutz ID, et al. Among authors: leaf em. Science. 2023 Apr 21;380(6642):266-273. doi: 10.1126/science.adf6591. Epub 2023 Apr 20. Science. 2023. PMID: 37079676
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP. McLeod B, et al. Among authors: leaf em. Immunity. 2022 Sep 13;55(9):1680-1692.e8. doi: 10.1016/j.immuni.2022.07.015. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977542 Free PMC article.
Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.
Dharmarajan S, Speer MY, Pierce K, Lally J, Leaf EM, Lin ME, Scatena M, Giachelli CM. Dharmarajan S, et al. Among authors: leaf em. Front Cardiovasc Med. 2021 Oct 29;8:687210. doi: 10.3389/fcvm.2021.687210. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34778386 Free PMC article.
25 results