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Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming.
Sun Z, Kwon JS, Ren Y, Chen S, Walker CK, Lu X, Cates K, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, Mennerick SJ, Diamond MI, Kim J, Tanzi RE, Holtzman DM, Yoo AS. Sun Z, et al. Among authors: fitzpatrick jaj. Science. 2024 Aug 2;385(6708):adl2992. doi: 10.1126/science.adl2992. Epub 2024 Aug 2. Science. 2024. PMID: 39088624
Endogenous recapitulation of Alzheimer's disease neuropathology through human 3D direct neuronal reprogramming.
Sun Z, Kwon JS, Ren Y, Chen S, Cates K, Lu X, Walker CK, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, Mennerick SJ, Diamond MI, Kim J, Tanzi RE, Holtzman DM, Yoo AS. Sun Z, et al. Among authors: fitzpatrick jaj. bioRxiv [Preprint]. 2023 May 25:2023.05.24.542155. doi: 10.1101/2023.05.24.542155. bioRxiv. 2023. PMID: 37292658 Free PMC article. Preprint.
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination.
Hou J, Zhou Y, Cai Z, Terekhova M, Swain A, Andhey PS, Guimaraes RM, Ulezko Antonova A, Qiu T, Sviben S, Strout G, Fitzpatrick JAJ, Chen Y, Gilfillan S, Kim DH, Van Dyken SJ, Artyomov MN, Colonna M. Hou J, et al. Among authors: fitzpatrick jaj. Cell Rep. 2023 Apr 25;42(4):112293. doi: 10.1016/j.celrep.2023.112293. Epub 2023 Mar 21. Cell Rep. 2023. PMID: 36952346 Free PMC article.
Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick JAJ, Sundaramoorthi H, Pak SC, Silverman GA, Knapp B, Filipuzzi I, Alford J, Reece-Hoyes J, Nigsch F, Murphy LO, Nyfeler B, Perlmutter DH. Li J, et al. Among authors: fitzpatrick jaj. Cell Mol Gastroenterol Hepatol. 2024;17(6):1007-1024. doi: 10.1016/j.jcmgh.2024.02.006. Epub 2024 Feb 7. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38336172 Free PMC article.
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis.
Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Zhang X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. Bailey AL, et al. JACC Basic Transl Sci. 2021 Apr;6(4):331-345. doi: 10.1016/j.jacbts.2021.01.002. Epub 2021 Feb 26. JACC Basic Transl Sci. 2021. PMID: 33681537 Free PMC article.
Functional characterization of the dural sinuses as a neuroimmune interface.
Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. Rustenhoven J, et al. Cell. 2021 Feb 18;184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27. Cell. 2021. PMID: 33508229 Free PMC article.
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis.
Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Lai L, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. Bailey AL, et al. bioRxiv [Preprint]. 2020 Nov 5:2020.11.04.364315. doi: 10.1101/2020.11.04.364315. bioRxiv. 2020. Update in: JACC Basic Transl Sci. 2021 Apr;6(4):331-345. doi: 10.1016/j.jacbts.2021.01.002. PMID: 33173875 Free PMC article. Updated. Preprint.
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhavale DD, Barclay AM, Borcik CG, Basore K, Gordon IR, Liu J, Milchberg MH, O'shea J, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT. Dhavale DD, et al. Among authors: fitzpatrick jaj. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.523303. doi: 10.1101/2023.01.09.523303. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 29;15(1):2750. doi: 10.1038/s41467-024-46832-5. PMID: 36711931 Free PMC article. Updated. Preprint.
95 results