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Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways.
Hamidzada H, Pascual-Gil S, Wu Q, Kent GM, Massé S, Kantores C, Kuzmanov U, Gomez-Garcia MJ, Rafatian N, Gorman RA, Wauchop M, Chen W, Landau S, Subha T, Atkins MH, Zhao Y, Beroncal E, Fernandes I, Nanthakumar J, Vohra S, Wang EY, Sadikov TV, Razani B, McGaha TL, Andreazza AC, Gramolini A, Backx PH, Nanthakumar K, Laflamme MA, Keller G, Radisic M, Epelman S. Hamidzada H, et al. Among authors: backx ph. Nat Cardiovasc Res. 2024 May;3(5):567-593. doi: 10.1038/s44161-024-00471-7. Epub 2024 May 7. Nat Cardiovasc Res. 2024. PMID: 39086373 Free PMC article.
Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.
Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Massé S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH. Wauchop M, et al. Among authors: backx ph. Biomaterials. 2023 Oct;301:122255. doi: 10.1016/j.biomaterials.2023.122255. Epub 2023 Jul 26. Biomaterials. 2023. PMID: 37651922 Free PMC article.
Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3.
Reitz CJ, Tavassoli M, Kim DH, Shah S, Lakin R, Teng ACT, Zhou YQ, Li W, Hadipour-Lakmehsari S, Backx PH, Emili A, Oudit GY, Kuzmanov U, Gramolini AO. Reitz CJ, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2212118120. doi: 10.1073/pnas.2212118120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126683 Free PMC article.
Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20.
Hughes MC, Ramos SV, Brahmbhatt AN, Turnbull PC, Polidovitch NN, Garibotti MC, Schlattner U, Hawke TJ, Simpson JA, Backx PH, Perry CG. Hughes MC, et al. Among authors: backx ph. Redox Biol. 2024 Oct;76:103319. doi: 10.1016/j.redox.2024.103319. Epub 2024 Aug 20. Redox Biol. 2024. PMID: 39178732 Free PMC article.
TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
Li X, You J, Dai F, Wang S, Yang FH, Wang X, Ding Z, Huang J, Chen L, Abudureyimu M, Tang H, Yang X, Xiang Y, Backx PH, Ren J, Ge J, Zou Y, Wu J. Li X, et al. Among authors: backx ph. JACC Basic Transl Sci. 2023 Aug 9;8(12):1555-1573. doi: 10.1016/j.jacbts.2023.05.008. eCollection 2023 Dec. JACC Basic Transl Sci. 2023. PMID: 38205342 Free PMC article.
Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.
Lakin R, Polidovitch N, Yang S, Parikh M, Liu X, Debi R, Gao X, Chen W, Guzman C, Yakobov S, Izaddoustdar F, Wauchop M, Lei Q, Xu W, Nedospasov SA, Christoffels VM, Backx PH. Lakin R, et al. Among authors: backx ph. Cardiovasc Res. 2023 Dec 19;119(16):2607-2622. doi: 10.1093/cvr/cvad144. Cardiovasc Res. 2023. PMID: 37713664 Free PMC article.
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, Kislinger T, Yip CM, Backx PH, Gourdie RG, Hamilton RM, Gramolini AO. Teng ACT, et al. Among authors: backx ph. Nat Commun. 2022 Oct 18;13(1):6166. doi: 10.1038/s41467-022-33303-y. Nat Commun. 2022. PMID: 36257954 Free PMC article.
215 results