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An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.
Qassim A, Souzeau E, Siggs OM, Hassall MM, Han X, Griffiths HL, Frost NA, Vallabh NA, Kirwan JF, Menon G, Cree AJ, Galanopoulos A, Agar A, Healey PR, Graham SL, Landers J, Casson RJ, Gharahkhani P, Willoughby CE, Hewitt AW, Lotery AJ, MacGregor S, Craig JE. Qassim A, et al. Among authors: han x. Ophthalmology. 2020 Jul;127(7):901-907. doi: 10.1016/j.ophtha.2019.12.025. Epub 2020 Jan 7. Ophthalmology. 2020. PMID: 32081492
Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?
Ingold N, Campos AI, Han X, Ong JS, Gharahkhani P, Mackey DA, Rentería ME, Law MH, MacGregor S. Ingold N, et al. Among authors: han x. Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):25. doi: 10.1167/iovs.63.1.25. Invest Ophthalmol Vis Sci. 2022. PMID: 35050305 Free PMC article. Review.
Genetic Risk of Cardiovascular Disease Is Associated with Macular Ganglion Cell-Inner Plexiform Layer Thinning in an Early Glaucoma Cohort.
Marshall H, Mullany S, Han X, Berry EC, Hassall MM, Qassim A, Nguyen T, Hollitt GL, Knight LSW, Ridge B, Schmidt J, Crowley C, Schulz A, Mills RA, Agar A, Galanopoulos A, Landers J, Healey PR, Graham SL, Hewitt AW, Casson RJ, MacGregor S, Siggs OM, Craig JE. Marshall H, et al. Among authors: han x. Ophthalmol Sci. 2021 Dec 23;2(1):100108. doi: 10.1016/j.xops.2021.100108. eCollection 2022 Mar. Ophthalmol Sci. 2021. PMID: 36246177 Free PMC article.
High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma.
Marshall HN, Mullany S, Han X, Qassim A, He W, Hassall MM, Schmidt J, Thomson D, Nguyen TT, Berry EC, Knight LSW, Hollitt GL, Ridge B, Schulz A, Mills RA, Healey PR, Agar A, Galanopoulos A, Landers J, Graham SL, Hewitt AW, Casson RJ, MacGregor S, Siggs OM, Craig JE. Marshall HN, et al. Among authors: han x. Ophthalmology. 2023 Aug;130(8):830-836. doi: 10.1016/j.ophtha.2023.03.028. Epub 2023 Apr 10. Ophthalmology. 2023. PMID: 37044160
Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology.
Greatbatch CJ, Lu Q, Hung S, Tran SN, Wing K, Liang H, Han X, Zhou T, Siggs OM, Mackey DA, Liu GS, Cook AL, Powell JE, Craig JE, MacGregor S, Hewitt AW. Greatbatch CJ, et al. Among authors: han x. Ophthalmol Sci. 2024 Mar 5;4(4):100504. doi: 10.1016/j.xops.2024.100504. eCollection 2024 Jul-Aug. Ophthalmol Sci. 2024. PMID: 38682030 Free PMC article.
Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.
Siggs OM, Han X, Qassim A, Souzeau E, Kuruvilla S, Marshall HN, Mullany S, Mackey DA, Hewitt AW, Gharahkhani P, MacGregor S, Craig JE. Siggs OM, et al. Among authors: han x. JAMA Ophthalmol. 2021 Sep 1;139(9):1023-1028. doi: 10.1001/jamaophthalmol.2021.2440. JAMA Ophthalmol. 2021. PMID: 34264281 Free PMC article.
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.
MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, Law MH, Souzeau E, Sharma S, Lynn DJ, Beesley J, Sheldrick B, Mills RA, Landers J, Ruddle JB, Graham SL, Healey PR, White AJR, Casson RJ, Best S, Grigg JR, Goldberg I, Powell JE, Whiteman DC, Radford-Smith GL, Martin NG, Montgomery GW, Burdon KP, Mackey DA, Gharahkhani P, Craig JE, Hewitt AW. MacGregor S, et al. Among authors: han x. Nat Genet. 2018 Aug;50(8):1067-1071. doi: 10.1038/s41588-018-0176-y. Epub 2018 Jul 27. Nat Genet. 2018. PMID: 30054594 Free article.
Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies.
Han X, Souzeau E, Ong JS, An J, Siggs OM, Burdon KP, Best S, Goldberg I, Healey PR, Graham SL, Ruddle JB, Mills RA, Landers J, Galanopoulos A, White AJR, Casson R, Mackey DA, Hewitt AW, Gharahkhani P, Craig JE, MacGregor S. Han X, et al. JAMA Ophthalmol. 2019 Jan 1;137(1):28-35. doi: 10.1001/jamaophthalmol.2018.4477. JAMA Ophthalmol. 2019. PMID: 30267046 Free PMC article.
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