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Page 1
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling.
Domingues N, Catarino S, Cristóvão B, Rodrigues L, Carvalho FA, Sarmento MJ, Zuzarte M, Almeida J, Ribeiro-Rodrigues T, Correia-Rodrigues Â, Fernandes F, Rodrigues-Santos P, Aasen T, Santos NC, Korolchuk VI, Gonçalves T, Milosevic I, Raimundo N, Girão H. Domingues N, et al. Among authors: korolchuk vi. EMBO J. 2024 Sep;43(17):3627-3649. doi: 10.1038/s44318-024-00177-3. Epub 2024 Jul 23. EMBO J. 2024. PMID: 39044100 Free PMC article.
Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. Sasazawa Y, et al. Among authors: korolchuk vi. EMBO J. 2022 Nov 17;41(22):e111476. doi: 10.15252/embj.2022111476. Epub 2022 Oct 11. EMBO J. 2022. PMID: 36394115 Free PMC article.
Mitophagy as a guardian against cellular aging.
Kataura T, Wilson N, Ma G, Korolchuk VI. Kataura T, et al. Among authors: korolchuk vi. Autophagy. 2024 Oct 14:1-3. doi: 10.1080/15548627.2024.2414461. Online ahead of print. Autophagy. 2024. PMID: 39402011
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: korolchuk vi. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
Autophagy, aging, and age-related neurodegeneration.
Palmer JE, Wilson N, Son SM, Obrocki P, Wrobel L, Rob M, Takla M, Korolchuk VI, Rubinsztein DC. Palmer JE, et al. Among authors: korolchuk vi. Neuron. 2024 Oct 8:S0896-6273(24)00663-9. doi: 10.1016/j.neuron.2024.09.015. Online ahead of print. Neuron. 2024. PMID: 39406236 Free article. Review.
Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death.
Neves SP, Bomfim LM, Kataura T, Carvalho SG, Nogueira ML, Dias RB, Valverde LF, Gurgel Rocha CA, Soares MBP, Silva MMD, Batista AA, Korolchuk VI, Bezerra DP. Neves SP, et al. Among authors: korolchuk vi. Biomed Pharmacother. 2024 Aug;177:117059. doi: 10.1016/j.biopha.2024.117059. Epub 2024 Jul 1. Biomed Pharmacother. 2024. PMID: 38955086 Free article.
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Among authors: korolchuk vi. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.
Kataura T, Sedlackova L, Sun C, Kocak G, Wilson N, Banks P, Hayat F, Trushin S, Trushina E, Maddocks ODK, Oblong JE, Miwa S, Imoto M, Saiki S, Erskine D, Migaud ME, Sarkar S, Korolchuk VI. Kataura T, et al. Among authors: korolchuk vi. Cell Death Dis. 2024 May 31;15(5):382. doi: 10.1038/s41419-024-06770-y. Cell Death Dis. 2024. PMID: 38821960 Free PMC article.
88 results