Zacharias M - Search Results

1

Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB.

Chen SY, Fiedler MK, Gronauer TF, Omelko O, von Wrisberg MK, Wang T, Schneider S, Sieber SA, Zacharias M. Chen SY, et al. Among authors: zacharias m. Commun Biol. 2024 Jul 24;7(1):895. doi: 10.1038/s42003-024-06575-x. Commun Biol. 2024. PMID: 39043865 Free PMC article.

2

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site.

Chen SY, Feilen LP, Chávez-Gutiérrez L, Steiner H, Zacharias M. Chen SY, et al. Among authors: zacharias m. Commun Biol. 2023 Jun 24;6(1):670. doi: 10.1038/s42003-023-05039-y. Commun Biol. 2023. PMID: 37355752 Free PMC article.

3

How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations.

Chen SY, Zacharias M. Chen SY, et al. Among authors: zacharias m. ACS Chem Neurosci. 2020 Oct 21;11(20):3321-3332. doi: 10.1021/acschemneuro.0c00440. Epub 2020 Oct 6. ACS Chem Neurosci. 2020. PMID: 32960571

4

An internal docking site stabilizes substrate binding to γ-secretase: Analysis by molecular dynamics simulations.

Chen SY, Zacharias M. Chen SY, et al. Among authors: zacharias m. Biophys J. 2022 Jun 21;121(12):2330-2344. doi: 10.1016/j.bpj.2022.05.023. Epub 2022 May 20. Biophys J. 2022. PMID: 35598043 Free PMC article.

5

What Makes a Good Protein-Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism.

Chen SY, Zacharias M. Chen SY, et al. Among authors: zacharias m. ACS Cent Sci. 2023 Apr 14;9(5):969-979. doi: 10.1021/acscentsci.3c00003. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252344 Free PMC article.

6

How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion.

Chen SY, Koch M, Chávez-Gutiérrez L, Zacharias M. Chen SY, et al. Among authors: zacharias m. J Med Chem. 2023 Dec 28;66(24):16772-16782. doi: 10.1021/acs.jmedchem.3c01480. Epub 2023 Dec 7. J Med Chem. 2023. PMID: 38059872

7

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.

Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H. Feilen LP, et al. Among authors: zacharias m. Elife. 2022 May 17;11:e76090. doi: 10.7554/eLife.76090. Elife. 2022. PMID: 35579427 Free PMC article.

8

Intramembrane client recognition potentiates the chaperone functions of calnexin.

Bloemeke N, Meighen-Berger K, Hitzenberger M, Bach NC, Parr M, Coelho JP, Frishman D, Zacharias M, Sieber SA, Feige MJ. Bloemeke N, et al. Among authors: zacharias m. EMBO J. 2022 Dec 15;41(24):e110959. doi: 10.15252/embj.2022110959. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314723 Free PMC article.

9

The human signal peptidase complex acts as a quality control enzyme for membrane proteins.

Zanotti A, Coelho JPL, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russell RB, Lemberg MK, Feige MJ. Zanotti A, et al. Among authors: zacharias m. Science. 2022 Dec 2;378(6623):996-1000. doi: 10.1126/science.abo5672. Epub 2022 Dec 1. Science. 2022. PMID: 36454823

10

A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis.

Rottenaicher GJ, Absmeier RM, Meier L, Zacharias M, Buchner J. Rottenaicher GJ, et al. Among authors: zacharias m. Commun Biol. 2023 Feb 23;6(1):209. doi: 10.1038/s42003-023-04574-y. Commun Biol. 2023. PMID: 36823438 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

551 results

Search Page

Filters