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Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia.
Huang YH, Lin SY, Ou LC, Huang WC, Chao PK, Chang YC, Chang HF, Lee PT, Yeh TK, Kuo YH, Tien YW, Xi JH, Tao PL, Chen PY, Chuang JY, Shih C, Chen CT, Tung CW, Loh HH, Ueng SH, Yeh SH. Huang YH, et al. Among authors: tien yw. Cell Chem Biol. 2024 Nov 21;31(11):1885-1898.e10. doi: 10.1016/j.chembiol.2024.06.013. Epub 2024 Jul 17. Cell Chem Biol. 2024. PMID: 39025070
The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.
Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: tien yw. Eur J Med Chem. 2019 Apr 1;167:312-323. doi: 10.1016/j.ejmech.2019.01.063. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30776693
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Yeh TK, Song JS, Chang PW, Yu JC, Chang CH, Liao FY, Tien YW, Kuppusamy R, Li AS, Chen CH, Chen CW, Lin LM, Chang HH, Huang CH, Yao JY, Wu MH, Peng YH, Hsueh CC, Hsiao WC, Chen PH, Lin CY, Hsieh SH, Shih C, Hung MS, Wu SY, Kuo CC, Ueng SH. Yeh TK, et al. Among authors: tien yw. Eur J Med Chem. 2022 Feb 5;229:114043. doi: 10.1016/j.ejmech.2021.114043. Epub 2021 Dec 8. Eur J Med Chem. 2022. PMID: 34929581
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Lin SY, Tien YW, Ke YY, Chang YC, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: tien yw. Bioorg Chem. 2022 Nov;128:105905. doi: 10.1016/j.bioorg.2022.105905. Epub 2022 Jun 2. Bioorg Chem. 2022. PMID: 35710525
DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.
Lin SY, Chang YC, Tien YW, Kuo YH, Chang HF, Ou LC, Chen YP, Chang KH, Hsu YT, Huang YC, Yang CM, Law PY, Xi JH, Tao PL, Loh HH, Yeh TK, Zhuang H, Hsieh HP, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: tien yw. J Med Chem. 2024 Nov 14;67(21):19777-19790. doi: 10.1021/acs.jmedchem.4c02107. Epub 2024 Oct 29. J Med Chem. 2024. PMID: 39473174
153 results