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Page 1
Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Siegel DS, Hui HC, Pitts J, Vermillion MS, Ishida K, Rautiola D, Keeney M, Irshad H, Zhang L, Chun K, Chin G, Goyal B, Doerffler E, Yang H, Clarke MO, Palmiotti C, Vijjapurapu A, Riola NC, Stray K, Murakami E, Ma B, Wang T, Zhao X, Xu Y, Lee G, Marchand B, Seung M, Nayak A, Tomkinson A, Kadrichu N, Ellis S, Barauskas O, Feng JY, Perry JK, Perron M, Bilello JP, Kuehl PJ, Subramanian R, Cihlar T, Mackman RL. Siegel DS, et al. Among authors: tomkinson a. J Med Chem. 2024 Aug 8;67(15):12945-12968. doi: 10.1021/acs.jmedchem.4c00899. Epub 2024 Jul 17. J Med Chem. 2024. PMID: 39018526
Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
Schmidt S, Mengistu M, Daffis S, Ahmadi-Erber S, Deutschmann D, Grigoriev T, Chu R, Leung C, Tomkinson A, Uddin MN, Moshkani S, Robek MD, Perry J, Lauterbach H, Orlinger K, Fletcher SP, Balsitis S. Schmidt S, et al. Among authors: tomkinson a. J Infect Dis. 2024 Apr 12;229(4):1077-1087. doi: 10.1093/infdis/jiad340. J Infect Dis. 2024. PMID: 37602681
Global screening of base excision repair in nucleosome core particles.
Sutton TB, Sawyer DL, Naila T, Sweasy JB, Tomkinson AE, Delaney S. Sutton TB, et al. Among authors: tomkinson ae. DNA Repair (Amst). 2024 Dec;144:103777. doi: 10.1016/j.dnarep.2024.103777. Epub 2024 Oct 19. DNA Repair (Amst). 2024. PMID: 39476546
Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Huang X, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S. Lin X, et al. Among authors: tomkinson ae. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7. doi: 10.1016/j.molcel.2024.09.020. Epub 2024 Oct 8. Mol Cell. 2024. PMID: 39383878
Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S. Lin X, et al. Among authors: tomkinson ae. bioRxiv [Preprint]. 2024 Mar 14:2024.03.12.584665. doi: 10.1101/2024.03.12.584665. bioRxiv. 2024. Update in: Mol Cell. 2024 Oct 17;84(20):3916-3931.e7. doi: 10.1016/j.molcel.2024.09.020 PMID: 38559022 Free PMC article. Updated. Preprint.
Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial.
Whitehouse T, Hossain A, Perkins GD, Gordon AC, Bion J, Young D, McAuley D, Singer M, Lord J, Gates S, Veenith T, MacCallum NS, Yeung J, Innes R, Welters I, Boota N, Skilton E, Ghuman B, Hill M, Regan SE, Mistry D, Lall R; STRESS-L Collaborators. Whitehouse T, et al. JAMA. 2023 Nov 7;330(17):1641-1652. doi: 10.1001/jama.2023.20134. JAMA. 2023. PMID: 37877587 Free PMC article.
Mammalian DNA ligases; roles in maintaining genome integrity.
Sallmyr A, Bhandari SK, Naila T, Tomkinson AE. Sallmyr A, et al. Among authors: tomkinson ae. J Mol Biol. 2024 Jan 1;436(1):168276. doi: 10.1016/j.jmb.2023.168276. Epub 2023 Sep 13. J Mol Biol. 2024. PMID: 37714297 Review.
FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration.
Kodavati M, Wang H, Guo W, Mitra J, Hegde PM, Provasek V, Maloji Rao VH, Vedula I, Zhang A, Mitra S, Tomkinson AE, Hamilton DJ, Bosch LVD, Hegde ML. Kodavati M, et al. Among authors: tomkinson ae. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-3152718. doi: 10.21203/rs.3.rs-3152718/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Mar 9;15(1):2156. doi: 10.1038/s41467-024-45978-6 PMID: 37502965 Free PMC article. Updated. Preprint.
234 results