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Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
Engel M, Hindie V, Lopez-Garcia LA, Stroba A, Schaeffer F, Adrian I, Imig J, Idrissova L, Nastainczyk W, Zeuzem S, Alzari PM, Hartmann RW, Piiper A, Biondi RM. Engel M, et al. EMBO J. 2006 Nov 29;25(23):5469-80. doi: 10.1038/sj.emboj.7601416. Epub 2006 Nov 16. EMBO J. 2006. PMID: 17110931 Free PMC article.
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M. Stroba A, et al. Among authors: engel m. J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499. J Med Chem. 2009. PMID: 19606904
Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).
Dettori R, Sonzogni S, Meyer L, Lopez-Garcia LA, Morrice NA, Zeuzem S, Engel M, Piiper A, Neimanis S, Frödin M, Biondi RM. Dettori R, et al. Among authors: engel m. J Biol Chem. 2009 Oct 30;284(44):30318-27. doi: 10.1074/jbc.M109.051151. Epub 2009 Sep 1. J Biol Chem. 2009. PMID: 19723632 Free PMC article.
PIF-pocket as a target for C. albicans Pkh selective inhibitors.
Pastor-Flores D, Schulze JO, Bahí A, Giacometti R, Ferrer-Dalmau J, Passeron S, Engel M, Süss E, Casamayor A, Biondi RM. Pastor-Flores D, et al. Among authors: engel m. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. doi: 10.1021/cb400452z. Epub 2013 Aug 22. ACS Chem Biol. 2013. PMID: 23911092
1,266 results