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Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice.
Smith CW, Campos J, Brown HC, Jooss NJ, Ivanova VS, Harbi M, Garcia-Quintanilla L, Jossi S, Perez-Toledo M, Rookes K, Brill A, Theodore LN, Owens T, LaStant J, Foulke MC, Mukai S, Francesco M, Storek M, Hicks A, Langrish C, Nunn PA, Cunningham AF, Chauhan A, Thomas MR, Watson SP, Nicolson PLR. Smith CW, et al. Among authors: storek m. Blood Adv. 2024 Nov 12;8(21):5557-5570. doi: 10.1182/bloodadvances.2024012713. Blood Adv. 2024. PMID: 38968150
Long-term efficacy and safety of continued complement C1s inhibition with sutimlimab in cold agglutinin disease: CADENZA study Part B.
Röth A, Berentsen S, Barcellini W, D'Sa S, Jilma B, Michel M, Weitz IC, Yamaguchi M, Nishimura JI, Vos JMI, Cid J, Storek M, Wong N, Yoo R, Jayawardene D, Srivastava S, Wardęcki M, Shafer F, Lee M, Broome CM. Röth A, et al. Among authors: storek m. EClinicalMedicine. 2024 Jul 18;74:102733. doi: 10.1016/j.eclinm.2024.102733. eCollection 2024 Aug. EClinicalMedicine. 2024. PMID: 39091672 Free PMC article.
C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement.
Liu F, Ryan ST, Fahnoe KC, Morgan JG, Cheung AE, Storek MJ, Best A, Chen HA, Locatelli M, Xu S, Schmidt E, Schmidt-Jiménez LF, Bieber K, Henderson JM, Lian CG, Verschoor A, Ludwig RJ, Benigni A, Remuzzi G, Salant DJ, Kalled SL, Thurman JM, Holers VM, Violette SM, Wawersik S. Liu F, et al. Among authors: storek mj. Mol Ther. 2024 Apr 3;32(4):1061-1079. doi: 10.1016/j.ymthe.2024.02.001. Epub 2024 Feb 20. Mol Ther. 2024. PMID: 38382529 Free PMC article.
Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies.
Rumsey JW, Lorance C, Jackson M, Sasserath T, McAleer CW, Long CJ, Goswami A, Russo MA, Raja SM, Gable KL, Emmett D, Hobson-Webb LD, Chopra M, Howard JF Jr, Guptill JT, Storek MJ, Alonso-Alonso M, Atassi N, Panicker S, Parry G, Hammond T, Hickman JJ. Rumsey JW, et al. Among authors: storek mj. Adv Ther (Weinh). 2022 Jun;5(6):2200030. doi: 10.1002/adtp.202200030. Epub 2022 Apr 5. Adv Ther (Weinh). 2022. PMID: 36211621 Free PMC article.
34 results