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From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation.
Soni D, Borriello F, Scott DA, Feru F, DeLeon M, Brightman SE, Cheng WK, Melhem G, Smith JA, Ramirez JC, Barman S, Cameron M, Kelly A, Walker K, Nanishi E, van Haren SD, Phan T, Qi Y, Kinsey R, Raczy MM, Ozonoff A, Pettengill MA, Hubbell JA, Fox CB, Dowling DJ, Levy O. Soni D, et al. Sci Adv. 2024 Jul 5;10(27):eadg3747. doi: 10.1126/sciadv.adg3747. Epub 2024 Jul 3. Sci Adv. 2024. PMID: 38959314 Free PMC article.
Precision Vaccine Development: Cues From Natural Immunity.
Barman S, Soni D, Brook B, Nanishi E, Dowling DJ. Barman S, et al. Among authors: soni d. Front Immunol. 2022 Feb 10;12:662218. doi: 10.3389/fimmu.2021.662218. eCollection 2021. Front Immunol. 2022. PMID: 35222350 Free PMC article. Review.
Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells.
Chew K, Lee B, van Haren SD, Nanishi E, O'Meara T, Splaine JB, DeLeon M, Soni D, Seo HS, Dhe-Paganon S, Ozonoff A, Smith JA, Levy O, Dowling DJ. Chew K, et al. Among authors: soni d. bioRxiv [Preprint]. 2022 Jul 11:2022.06.17.496630. doi: 10.1101/2022.06.17.496630. bioRxiv. 2022. PMID: 35860217 Free PMC article. Preprint.
Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers.
Barman S, Borriello F, Brook B, Pietrasanta C, De Leon M, Sweitzer C, Menon M, van Haren SD, Soni D, Saito Y, Nanishi E, Yi S, Bobbala S, Levy O, Scott EA, Dowling DJ. Barman S, et al. Among authors: soni d. ACS Chem Biol. 2022 Sep 16;17(9):2559-2571. doi: 10.1021/acschembio.2c00497. Epub 2022 Aug 26. ACS Chem Biol. 2022. PMID: 36028220 Free PMC article.
The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo.
Brook B, Fatou B, Kumar Checkervarty A, Barman S, Sweitzer C, Bosco AN, Sherman AC, Baden LR, Morrocchi E, Sanchez-Schmitz G, Palma P, Nanishi E, O'Meara TR, McGrath ME, Frieman MB, Soni D, van Haren SD, Ozonoff A, Diray-Arce J, Steen H, Dowling DJ, Levy O. Brook B, et al. Among authors: soni d. Res Sq [Preprint]. 2022 Dec 21:rs.3.rs-2395118. doi: 10.21203/rs.3.rs-2395118/v1. Res Sq. 2022. PMID: 36597547 Free PMC article. Preprint.
233 results