Knollmann BC - Search Results

1

Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product.

Thorpe MP, Blackwell DJ, Knollmann BC, Johnston JN. Thorpe MP, et al. Among authors: knollmann bc. J Med Chem. 2024 Jul 25;67(14):12205-12220. doi: 10.1021/acs.jmedchem.4c00923. Epub 2024 Jul 3. J Med Chem. 2024. PMID: 38958200 Free PMC article.

2

Structure-Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics.

Smith AN, Thorpe MP, Blackwell DJ, Batiste SM, Hopkins CR, Schley ND, Knollmann BC, Johnston JN. Smith AN, et al. Among authors: knollmann bc. ACS Med Chem Lett. 2022 Oct 5;13(11):1755-1762. doi: 10.1021/acsmedchemlett.2c00377. eCollection 2022 Nov 10. ACS Med Chem Lett. 2022. PMID: 36385927 Free PMC article.

3

The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency.

Kim K, Blackwell DJ, Yuen SL, Thorpe MP, Johnston JN, Cornea RL, Knollmann BC. Kim K, et al. Among authors: knollmann bc. J Mol Cell Cardiol. 2023 Jul;180:1-9. doi: 10.1016/j.yjmcc.2023.04.005. Epub 2023 Apr 18. J Mol Cell Cardiol. 2023. PMID: 37080450 Free PMC article.

4

RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease.

Schmeckpeper J, Kim K, George SA, Blackwell DJ, Brennan JA, Efimov IR, Knollmann BC. Schmeckpeper J, et al. Among authors: knollmann bc. J Mol Cell Cardiol. 2023 Aug;181:67-78. doi: 10.1016/j.yjmcc.2023.05.009. Epub 2023 Jun 5. J Mol Cell Cardiol. 2023. PMID: 37285929 Free PMC article.

5

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET.

Šeflová J, Schwarz JA, Smith AN, Svensson B, Blackwell DJ, Phillips TA, Nikolaienko R, Bovo E, Rebbeck RT, Zima AV, Thomas DD, Van Petegem F, Knollmann BC, Johnston JN, Robia SL, Cornea RL. Šeflová J, et al. Among authors: knollmann bc. ACS Chem Biol. 2023 Oct 20;18(10):2290-2299. doi: 10.1021/acschembio.3c00376. Epub 2023 Sep 28. ACS Chem Biol. 2023. PMID: 37769131

6

Ryanodine receptor inhibition with acute dantrolene treatment reduces arrhythmia susceptibility in human hearts.

George SA, Brennan-McLean JA, Trampel KA, Rytkin E, Faye NR, Knollmann BC, Efimov IR. George SA, et al. Among authors: knollmann bc. Am J Physiol Heart Circ Physiol. 2023 Oct 1;325(4):H720-H728. doi: 10.1152/ajpheart.00103.2023. Epub 2023 Aug 11. Am J Physiol Heart Circ Physiol. 2023. PMID: 37566110 Free article.

7

Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases.

Do TQ, Knollmann BC. Do TQ, et al. Among authors: knollmann bc. Annu Rev Pharmacol Toxicol. 2024 Oct 7. doi: 10.1146/annurev-pharmtox-061724-080739. Online ahead of print. Annu Rev Pharmacol Toxicol. 2024. PMID: 39374431 Review.

8

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts.

Joshi P, Estes S, DeMazumder D, Knollmann BC, Dey S. Joshi P, et al. Among authors: knollmann bc. Elife. 2023 Dec 11;12:RP88638. doi: 10.7554/eLife.88638. Elife. 2023. PMID: 38078905 Free PMC article. Clinical Trial.

9

Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.

Deb A, Tow BD, Qing Y, Walker M, Hodges ER, Stewart JA Jr, Knollmann BC, Zheng Y, Wang Y, Liu B. Deb A, et al. Among authors: knollmann bc. Cells. 2023 Jan 4;12(2):204. doi: 10.3390/cells12020204. Cells. 2023. PMID: 36672139 Free PMC article.

10

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy.

Sequeira V, Wang L, Wijnker PJM, Kim K, Pinto JR, Dos Remedios C, Redwood C, Knollmann BC, van der Velden J. Sequeira V, et al. Among authors: knollmann bc. J Mol Cell Cardiol Plus. 2022 Sep;1:100007. doi: 10.1016/j.jmccpl.2022.100007. J Mol Cell Cardiol Plus. 2022. PMID: 37159677 Free PMC article.

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