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Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: lenz c. bioRxiv [Preprint]. 2024 Feb 18:2024.02.18.580805. doi: 10.1101/2024.02.18.580805. bioRxiv. 2024. Update in: J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. PMID: 38405908 Free PMC article. Updated. Preprint.
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: lenz c. J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. Epub 2024 Jul 19. J Med Chem. 2024. PMID: 39028937
The Lateral Corticospinal Tract Sign: An MRI Marker for Amyotrophic Lateral Sclerosis.
Wendebourg MJ, Kesenheimer E, Sander L, Weigel M, Weidensteiner C, Haas T, Madoerin P, Diebold M, Deigendesch N, Neuhaus D, Naumann N, Neuwirth C, Braun N, Weber M, Granziera C, Scheurer E, Lenz C, Schweikert K, Sinnreich M, Lieb J, Bieri O, Schlaeger R. Wendebourg MJ, et al. Among authors: lenz c. Radiology. 2024 Sep;312(3):e231630. doi: 10.1148/radiol.231630. Radiology. 2024. PMID: 39287519
Skin microdialysis detects distinct immunologic patterns in chronic inflammatory skin diseases.
Hollstein MM, Traidl S, Heetfeld A, Forkel S, Leha A, Alkon N, Ruwisch J, Lenz C, Schön MP, Schmelz M, Brunner P, Steinhoff M, Buhl T. Hollstein MM, et al. Among authors: lenz c. J Allergy Clin Immunol. 2024 Aug 12:S0091-6749(24)00782-6. doi: 10.1016/j.jaci.2024.06.024. Online ahead of print. J Allergy Clin Immunol. 2024. PMID: 39142443 Free article.
382 results