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Multiple recent HCAR2 structures demonstrate a highly dynamic ligand binding and G protein activation mode.
Nat Commun. 2024 Jun 25;15(1):5364. doi: 10.1038/s41467-024-49536-y.
Nat Commun. 2024.
PMID: 38918366
Free PMC article.
Review.
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91.
Shenol A, Lückmann M, Trauelsen M, Lambrughi M, Tiberti M, Papaleo E, Frimurer TM, Schwartz TW.
Shenol A, et al.
Mol Cell. 2024 Mar 7;84(5):955-966.e4. doi: 10.1016/j.molcel.2024.01.011. Epub 2024 Feb 6.
Mol Cell. 2024.
PMID: 38325379
Free article.
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Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action.
Lückmann M, Shenol A, Nissen TAD, Petersen JE, Kouvchinov D, Schwartz TW, Frimurer TM.
Lückmann M, et al. Among authors: shenol a.
ACS Med Chem Lett. 2022 Nov 2;13(12):1839-1847. doi: 10.1021/acsmedchemlett.2c00160. eCollection 2022 Dec 8.
ACS Med Chem Lett. 2022.
PMID: 36518697
Free PMC article.
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Optimization and in-vitro/in-vivo evaluation of doxorubicin-loaded chitosan-alginate nanoparticles using a melanoma mouse model.
Yoncheva K, Merino M, Shenol A, Daskalov NT, Petkov PS, Vayssilov GN, Garrido MJ.
Yoncheva K, et al. Among authors: shenol a.
Int J Pharm. 2019 Feb 10;556:1-8. doi: 10.1016/j.ijpharm.2018.11.070. Epub 2018 Dec 6.
Int J Pharm. 2019.
PMID: 30529664
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