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Page 1
Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice.
Talvard-Balland N, Braun LM, Dixon KO, Zwick M, Engel H, Hartmann A, Duquesne S, Penter L, Andrieux G, Rindlisbacher L, Acerbis A, Ehmann J, Köllerer C, Ansuinelli M, Rettig A, Moschallski K, Apostolova P, Brummer T, Illert AL, Schramm MA, Cheng Y, Köttgen A, Duyster J, Menssen HD, Ritz J, Blazar BR, Boerries M, Schmitt-Gräff A, Sariipek N, Van Galen P, Buescher JM, Cabezas-Wallscheid N, Pahl HL, Pearce EL, Soiffer RJ, Wu CJ, Vago L, Becher B, Köhler N, Wertheimer T, Kuchroo VK, Zeiser R. Talvard-Balland N, et al. Among authors: kuchroo vk. J Clin Invest. 2024 Jun 25;134(16):e177460. doi: 10.1172/JCI177460. J Clin Invest. 2024. PMID: 38916965 Free PMC article.
Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state.
Mangani D, Subramanian A, Huang L, Cheng H, Krovi SH, Wu Y, Yang D, Moreira TG, Escobar G, Schnell A, Dixon KO, Krishnan RK, Singh V, Sobel RA, Weiner HL, Kuchroo VK, Anderson AC. Mangani D, et al. Among authors: kuchroo vk. Immunity. 2024 Oct 15:S1074-7613(24)00480-1. doi: 10.1016/j.immuni.2024.09.017. Online ahead of print. Immunity. 2024. PMID: 39447575
TIGIT predominantly regulates the immune response via regulatory T cells.
Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. Kurtulus S, et al. Among authors: kuchroo vk. J Clin Invest. 2024 Jul 1;134(13):e183278. doi: 10.1172/JCI183278. J Clin Invest. 2024. PMID: 38949028 Free PMC article. No abstract available.
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.
Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Hafler D, et al. Res Sq [Preprint]. 2021 Jun 8:rs.3.rs-133494. doi: 10.21203/rs.3.rs-133494/v1. Res Sq. 2021. Update in: Nat Immunol. 2022 Apr;23(4):632-642. doi: 10.1038/s41590-022-01152-y. PMID: 34127967 Free PMC article. Updated. Preprint.
Neuropeptide signalling orchestrates T cell differentiation.
Hou Y, Sun L, LaFleur MW, Huang L, Lambden C, Thakore PI, Geiger-Schuller K, Kimura K, Yan L, Zang Y, Tang R, Shi J, Barilla R, Deng L, Subramanian A, Wallrapp A, Choi HS, Kye YC, Ashenberg O, Schiebinger G, Doench JG, Chiu IM, Regev A, Sharpe AH, Kuchroo VK. Hou Y, et al. Among authors: kuchroo vk. Nature. 2024 Oct 16. doi: 10.1038/s41586-024-08049-w. Online ahead of print. Nature. 2024. PMID: 39415015
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells.
Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, Krishnan RK, Kozoriz D, Ma S, Sankar V, Notarbartolo S, Buenrostro JD, Sallusto F, Patsopoulos NA, Rozenblatt-Rosen O, Kuchroo VK, Regev A. Thakore PI, et al. Among authors: kuchroo vk. Nat Immunol. 2024 Aug;25(8):1395-1410. doi: 10.1038/s41590-024-01901-1. Epub 2024 Jul 15. Nat Immunol. 2024. PMID: 39009838
Autoimmunity and the microbiome.
Cox LM, Kuchroo VK. Cox LM, et al. Among authors: kuchroo vk. Immunol Rev. 2024 Aug;325(1):4-8. doi: 10.1111/imr.13363. Epub 2024 Jul 9. Immunol Rev. 2024. PMID: 38980198 No abstract available.
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy.
Krueger JG, Eyerich K, Kuchroo VK, Ritchlin CT, Abreu MT, Elloso MM, Fourie A, Fakharzadeh S, Sherlock JP, Yang YW, Cua DJ, McInnes IB. Krueger JG, et al. Among authors: kuchroo vk. Front Immunol. 2024 Apr 15;15:1331217. doi: 10.3389/fimmu.2024.1331217. eCollection 2024. Front Immunol. 2024. PMID: 38686385 Free PMC article. Review.
419 results