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11 results

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Page 1
Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning.
Monti R, Eick L, Hudjashov G, Läll K, Kanoni S, Wolford BN, Wingfield B, Pain O, Wharrie S, Jermy B, McMahon A, Hartonen T, Heyne H, Mars N, Lambert S; Genes and Health Research Team; Hveem K, Inouye M, van Heel DA, Mägi R, Marttinen P, Ripatti S, Ganna A, Lippert C. Monti R, et al. Among authors: hartonen t. Am J Hum Genet. 2024 Jul 11;111(7):1431-1447. doi: 10.1016/j.ajhg.2024.06.003. Epub 2024 Jun 21. Am J Hum Genet. 2024. PMID: 38908374
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.
Jermy B, Läll K, Wolford BN, Wang Y, Zguro K, Cheng Y, Kanai M, Kanoni S, Yang Z, Hartonen T, Monti R, Wanner J, Youssef O; Estonian Biobank research team; FinnGen; Lippert C, van Heel D, Okada Y, McCartney DL, Hayward C, Marioni RE, Furini S, Renieri A, Martin AR, Neale BM, Hveem K, Mägi R, Palotie A, Heyne H, Mars N, Ganna A, Ripatti S. Jermy B, et al. Among authors: hartonen t. Nat Commun. 2024 Jun 12;15(1):5007. doi: 10.1038/s41467-024-48938-2. Nat Commun. 2024. PMID: 38866767 Free PMC article.
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model.
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A. Vartiainen P, et al. Among authors: hartonen t. Lancet Digit Health. 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9. Lancet Digit Health. 2023. PMID: 37890904 Free article.
Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry).
Viippola E, Kuitunen S, Rodosthenous RS, Vabalas A, Hartonen T, Vartiainen P, Demmler J, Vuorinen AL, Liu A, Havulinna AS, Llorens V, Detrois KE, Wang F, Ferro M, Karvanen A, German J, Jukarainen S, Gracia-Tabuenca J, Hiekkalinna T, Koskelainen S, Kiiskinen T, Lahtela E, Lemmelä S, Paajanen T, Siirtola H, Reeve MP, Kristiansson K, Brunfeldt M, Aavikko M, Gen F, Perola M, Ganna A; FinnGen. Viippola E, et al. Among authors: hartonen t. Int J Epidemiol. 2023 Aug 2;52(4):e195-e200. doi: 10.1093/ije/dyad091. Int J Epidemiol. 2023. PMID: 37365732 Free PMC article. No abstract available.
Nationwide health, socio-economic and genetic predictors of COVID-19 vaccination status in Finland.
Hartonen T, Jermy B, Sõnajalg H, Vartiainen P, Krebs K, Vabalas A; FinnGen; Estonian Biobank Research Team; Leino T, Nohynek H, Sivelä J, Mägi R, Daly M, Ollila HM, Milani L, Perola M, Ripatti S, Ganna A. Hartonen T, et al. Nat Hum Behav. 2023 Jul;7(7):1069-1083. doi: 10.1038/s41562-023-01591-z. Epub 2023 Apr 20. Nat Hum Behav. 2023. PMID: 37081098 Free PMC article.
Sequence determinants of human gene regulatory elements.
Sahu B, Hartonen T, Pihlajamaa P, Wei B, Dave K, Zhu F, Kaasinen E, Lidschreiber K, Lidschreiber M, Daub CO, Cramer P, Kivioja T, Taipale J. Sahu B, et al. Among authors: hartonen t. Nat Genet. 2022 Mar;54(3):283-294. doi: 10.1038/s41588-021-01009-4. Epub 2022 Feb 21. Nat Genet. 2022. PMID: 35190730 Free PMC article.
Contribution of allelic imbalance to colorectal cancer.
Palin K, Pitkänen E, Turunen M, Sahu B, Pihlajamaa P, Kivioja T, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA. Palin K, et al. Among authors: hartonen t. Nat Commun. 2018 Sep 10;9(1):3664. doi: 10.1038/s41467-018-06132-1. Nat Commun. 2018. PMID: 30202008 Free PMC article.
11 results