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Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators.
Jadav R, Weiland F, Noordermeer SM, Carroll T, Gao Y, Wang J, Zhou H, Lamoliatte F, Toth R, Macartney T, Brown F, Hastie CJ, Alabert C, van Attikum H, Zenke F, Masson JY, Rouse J. Jadav R, et al. Among authors: noordermeer sm. Mol Cell Proteomics. 2024 Aug;23(8):100802. doi: 10.1016/j.mcpro.2024.100802. Epub 2024 Jun 15. Mol Cell Proteomics. 2024. PMID: 38880245 Free PMC article.
EXO1 protects BRCA1-deficient cells against toxic DNA lesions.
van de Kooij B, Schreuder A, Pavani R, Garzero V, Uruci S, Wendel TJ, van Hoeck A, San Martin Alonso M, Everts M, Koerse D, Callen E, Boom J, Mei H, Cuppen E, Luijsterburg MS, van Vugt MATM, Nussenzweig A, van Attikum H, Noordermeer SM. van de Kooij B, et al. Among authors: noordermeer sm. Mol Cell. 2024 Feb 15;84(4):659-674.e7. doi: 10.1016/j.molcel.2023.12.039. Epub 2024 Jan 23. Mol Cell. 2024. PMID: 38266640 Free article.
(Single-stranded DNA) gaps in understanding BRCAness.
Schreuder A, Wendel TJ, Dorresteijn CGV, Noordermeer SM. Schreuder A, et al. Among authors: noordermeer sm. Trends Genet. 2024 Sep;40(9):757-771. doi: 10.1016/j.tig.2024.04.013. Epub 2024 May 23. Trends Genet. 2024. PMID: 38789375 Free article. Review.
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I, Dello Stritto MR, Mütze M, Braunshier S, Mengoli V, Reginato G, Võ HMP, Jimeno S, Acharya A, Roy M, Sanchez A, Halder S, Howard SM, Guérois R, Huertas P, Noordermeer SM, Seidel R, Cejka P. Ceppi I, et al. Among authors: noordermeer sm. Nature. 2024 Oct;634(8033):492-500. doi: 10.1038/s41586-024-07909-9. Epub 2024 Sep 11. Nature. 2024. PMID: 39261728 Free PMC article.
EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells.
van de Kooij B, Schreuder A, Pavani RS, Garzero V, Van Hoeck A, San Martin Alonso M, Koerse D, Wendel TJ, Callen E, Boom J, Mei H, Cuppen E, Nussenzweig A, van Attikum H, Noordermeer SM. van de Kooij B, et al. Among authors: noordermeer sm. bioRxiv [Preprint]. 2023 Feb 24:2023.02.24.529205. doi: 10.1101/2023.02.24.529205. bioRxiv. 2023. PMID: 37720033 Free PMC article. Preprint.
The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.
Adam S, Rossi SE, Moatti N, De Marco Zompit M, Xue Y, Ng TF, Álvarez-Quilón A, Desjardins J, Bhaskaran V, Martino G, Setiaputra D, Noordermeer SM, Ohsumi TK, Hustedt N, Szilard RK, Chaudhary N, Munro M, Veloso A, Melo H, Yin SY, Papp R, Young JTF, Zinda M, Stucki M, Durocher D. Adam S, et al. Among authors: noordermeer sm. Nat Cancer. 2021 Dec;2(12):1357-1371. doi: 10.1038/s43018-021-00266-w. Epub 2021 Nov 11. Nat Cancer. 2021. PMID: 35121901 Free article.
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.
van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen TET, van Schie JJM, San Martin Alonso M, Boer DEC, González-Prieto R, Narayanan IV, Klaassen NHM, Wondergem AP, Roohollahi K, Dorsman JC, Hara Y, Vertegaal ACO, de Lange J, Walter JC, Noordermeer SM, Ljungman M, Ogi T, Wolthuis RMF, Luijsterburg MS. van der Weegen Y, et al. Among authors: noordermeer sm. Nat Cell Biol. 2021 Jun;23(6):595-607. doi: 10.1038/s41556-021-00688-9. Epub 2021 Jun 9. Nat Cell Biol. 2021. PMID: 34108663 Free PMC article.
26 results